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Electrophysiological follow-up of acute and chronic experimental allergic encephalomyelitis in the Lewis rat


Cortical somatosensory evoked potentials (c-SEP) and flash visual evoked potentials (f-VEP) were serially recorded in acute monophasic and chronic relapsing experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE, a significantly delayed latency and broadened peak of the c-SEP were observed corresponding to the clinical onset, and then returned to normal with the disappearance of clinical signs. In chronic EAE, the c-SEP showed the same changes as in acute EAE, also reflecting the first attack, remission and relapsing phase. However, chronic EAE, when paralysis had recovered in the relapsing phase, showed c-SEP abnormalities suggestive of subclinical active lesions. In contrast, the f-VEP showed no obvious abnormalities in acute or chronic EAE. These findings suggest that the c-SEP is an objective and sensitive index for detecting clinical and pathological changes in acute and chronic EAE in the Lewis rat.

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Correspondence to Kazushi Deguchi.

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Deguchi, K., Takeuchi, H., Miki, H. et al. Electrophysiological follow-up of acute and chronic experimental allergic encephalomyelitis in the Lewis rat. Eur Arch Psychiatry Clin Nuerosci 242, 1–5 (1992).

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Key words

  • Experimental allergic encephalomyelitis
  • Demyelination
  • Evoked potentials
  • Multiple sclerosis