Cortical somatosensory evoked potentials (c-SEP) and flash visual evoked potentials (f-VEP) were serially recorded in acute monophasic and chronic relapsing experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE, a significantly delayed latency and broadened peak of the c-SEP were observed corresponding to the clinical onset, and then returned to normal with the disappearance of clinical signs. In chronic EAE, the c-SEP showed the same changes as in acute EAE, also reflecting the first attack, remission and relapsing phase. However, chronic EAE, when paralysis had recovered in the relapsing phase, showed c-SEP abnormalities suggestive of subclinical active lesions. In contrast, the f-VEP showed no obvious abnormalities in acute or chronic EAE. These findings suggest that the c-SEP is an objective and sensitive index for detecting clinical and pathological changes in acute and chronic EAE in the Lewis rat.
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Arezzo JC, Brosnan CF, Schroeder CE, Litwak MS, Bornstein MB (1988) Electrophysiological analysis of factors involved in the primary demyelinating diseases: the rabbit eye model system. Brain Res 462:286–300
Arnason BGW (1983) Relevance of experimental allergic encephalomyelitis to multiple sclerosis. Neurol Clin 1:765–782
Bilbool N, Kaitz M, Feinsod M, Soffer D, Abramsky O (1983) Visual evoked potentials in experimental allergic encephalomyelitis. J Neurol Sci 60:105–115
Chiappa KH, Jayakar P (1989) Evoked potentials in clinical medicine. In: Baker AB, Joynt RJ (eds) Clinical Neurology, Lippincott, Philadelphia London St Louis New York Sydney Tokyo, pp 1–66
Deguchi K, Takeuchi H, Miki H, Yamada A, Touge T, Terada S, Nishioka M (1991) Effects of FK506 on acute experimental allergic encephalomyelitis. Transplant Proc 23:3360–3362
Fox DA, Lewkowski JP, Cooper GP (1977) Acute and chronic effects of neonatal lead exposure on development of the visual evoked response in rats. Toxicol Appl Pharmacol 40:449–461
Goss-Sampson MA, Kriss A, Muddle JR, Thomas PK, Muller DPR (1988) Lumbar and cortical somatosensory evoked potentials in rats with vitamin E deficiency. J Neurol Neurosurg Psychiatry 51:432–435
Guerit JM, Argiles AM (1988) The sensitivity of multimodal evoked potentials in multiple sclerosis: A comparison with magnetic resonance imaging and cerebrospinal fluid analysis. Electroencephalogr Clin Neurophysiol 70:230–238
Hayreh SS, Massanari RM, Yamada T, Hayreh SMS (1981) Experimental allergic encephalomyelitis I. Optic nerve and central nervous system manifestations. Invest Opthalmol Vis Sci 21:256–269
Heininger K, Fierz W, Schäfer B, Hartung H-P, Wehling P, Toyka KV (1989) Electrophysiological investigations in adoptive transferred experimental autoimmune encephalomyelitis in the Lewis rat. Brain 112:537–552
Kaji R, Tanaka R, Kawaguchi S, McCormick F, Kameyama M (1986) Origin of short-latency somatosensory evoked potentials to median nerve stimulation in the cat: comparison of the recording montages and the effect of laminectomy. Brain 109:443–468
Kaji R, Suzumura A, Sumner AJ (1988) Physiological consequences of antiserum-mediated experimental demyelination in CNS. Brain 111:675–694
Kraut MA, Arezzo JC, Vaughan HG jr (1985) Intracortical generators of the flash VEP in monkeys. Electroencephalogr Clin Neurophysiol 62:300–312
Nuwer MR, Packwood JW, Myers LW, Ellison GW (1987) Evoked potentials predict the clinical changes in a multiple sclerosis drug study. Neurology 37:1754–1761
Pender MP (1986) Conduction block due to demyelination at the ventral root exit zone in experimental allergic encephalomyelitis. Brain Res 367:398–401
Pender MP (1989) Recovery from acute experimental allergic encephalomyelitis in the Lewis rat. Early restoration of nerve conduction and repair by Schwann cells and oligodendrocytes. Brain 112:393–416
Pender MP, Sears TA (1986) Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: a histological and electrophysiological study. J Neurol Sci 72:231–242
Sibley WA, Poser CM, Alter M (1989) Multiple Sclerosis. In: Roland LP (ed) Merritt's textbook of NEUROLOGY. Lea & Febiger, Philadelphia London, pp 741–760
Wall PD (1970) The sensory and motor role of impulse travelling in the dorsal columns towards cerebral cortex. Brain 93:505–524
Zeneroli ML, Penneo A, Parrinelloo G, Cremonini C, Ventura E (1981) Comparative evaluation of visual evoked potentials in experimental hepatic encephalopathy and in pharmacologically induced coma-like states in rat. Life Sci 28:1507–1515
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Deguchi, K., Takeuchi, H., Miki, H. et al. Electrophysiological follow-up of acute and chronic experimental allergic encephalomyelitis in the Lewis rat. Eur Arch Psychiatry Clin Nuerosci 242, 1–5 (1992). https://doi.org/10.1007/BF02190335
- Experimental allergic encephalomyelitis
- Evoked potentials
- Multiple sclerosis