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Senile dementia of the Alzheimer type in the Lundby study

II. An attempt to identify possible risk factors

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In recent years research on senile dementia of the Alzheimer type (SDAT) has made progress within the field of pathology and to a certain extent in that of heredity. Within epidemiology, the search for risk factors is intensifying but the findings are still inconclusive. The present study of possible risk factors concentrates on environmental and personality factors. The total population of 2612 persons from a geographically delimited area, Lundby, two neighbouring parishes in southern Sweden, was examined in 1957 by one psychiatrist (Hagnell). A follow-up study of the same population, irrespective of domicile, was performed 15 years later, in 1972. Various precipitating as well as protective personality background factors were found to be significant for the outcome of SDAT, but no environmental factors appeared to be statistically significant in this cohort.

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This study has been supported by the following grants: The Bank of Sweden Tercentenary Foundation No. 71/2; The Swedish Medical Research Council Nos. 3474, 4803, 6008, 6881; Delegation for Social Research No. 83/64:1–2. The study was performed with the approval of the Ethical Committee of the Lund University Faculty of Medicine and with the permission of the Swedish Data Inspection Board.

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Hagnell, O., Franck, A., Gräsbeck, A. et al. Senile dementia of the Alzheimer type in the Lundby study. Eur Arch Psychiatry Clin Nuerosci 241, 231–235 (1992). https://doi.org/10.1007/BF02190258

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Key words

  • Alzheimer
  • Dementia
  • Longitudinal
  • Risk factors
  • Lundby Study