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Effects of morphine and nalorphine on the phenylquinone-induced syndrome in monkeys


Intraperitoneal injection of 6 mg/kg of phenyl-p-quinone produced a syndrome consisting of distorted limb and body positions in rhesus monkeys. Intramuscular injection of 1 mg/kg of morphine abolished the syndrome, whereas 16 mg/kg of nalorphine had no appreciable effects on the syndrome. One-half mg/kg of nalorphine reversed the inhibitory effects of 1 mg/kg of morphine on the syndrome.

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Pearl, J., Michel, C.R. & Bohnet, E.A. Effects of morphine and nalorphine on the phenylquinone-induced syndrome in monkeys. Psychopharmacologia 14, 266–270 (1969).

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  • Monkeys
  • Phenyl-p-quinone
  • Analgesics
  • Morphine
  • Nalorphine