Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effects of morphine and nalorphine on the phenylquinone-induced syndrome in monkeys

Summary

Intraperitoneal injection of 6 mg/kg of phenyl-p-quinone produced a syndrome consisting of distorted limb and body positions in rhesus monkeys. Intramuscular injection of 1 mg/kg of morphine abolished the syndrome, whereas 16 mg/kg of nalorphine had no appreciable effects on the syndrome. One-half mg/kg of nalorphine reversed the inhibitory effects of 1 mg/kg of morphine on the syndrome.

This is a preview of subscription content, log in to check access.

References

  1. Blane, G. F.: Blockade of bradykinin-induced nociception in the rat as a test for analgesic drugs with particular reference to morphine antagonists. J. Pharm. Pharmacol.19, 367–373 (1967).

  2. Blumberg, H., P. S. Wolf, andH. B. Dayton: Use of writhing test for evaluating analgesic activity of narcotic antagonists. Proc. Soc. exp. Biol. (N. Y.)118, 763–766 (1965).

  3. Keats, A. S., andJ. Telford: Nalorphine, a potent analgesic in man. J. Pharmacol. exp. Ther.117, 190–196 (1956).

  4. Lasagna, L., andH. K. Beecher: The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man. J. Pharmacol. exp. Ther.112, 356–363 (1954).

  5. Macaraeg, P. V. J., Jr,J. R. Bianchine, andL. Lasagna: Tolerance to druginduced writhing in mice. J, Pharmacol. exp. Ther.161, 130–140 (1968).

  6. Martin, W. R.: Opioid antagonists. Pharmacol. Rev.19, 463–521 (1967).

  7. Pearl, J., M. D. Aceto, andJ. J. Fitzgerald: Differences in antiwrithing activity of morphine and nalorphine over time and in slopes of the dose-response lines. Psychopharmacologia (Berl.)13, 341–345 (1968a).

  8. — — andL. S. Harris: Prevention of writhing and other effects of narcotics and narcotic antagonists in mice. J. Pharmacol. exp. Ther.160, 217–230 (1968b).

  9. —, andL. S. Harris: Inhibition of writhing by narcotic antagonists. J. Pharmacol. exp. Ther.154, 319–323 (1966).

  10. Siegel, S.: Nonparametric Statistics for the Behavioral Sciences, New York: McGraw Hill Book Co. 1956.

  11. Taber, R. I., D. D. Greenhouse, andS. Irwin: Inhibition of phenylquinone-induced writhing by narcotic antagonists. Nature (Lond.)204, 189 (1964).

  12. Weiss, B., andV. G. Laties: Analgesic effects in monkeys of morphine, nalorphine, and a benzomorphan narcotic antagonist. J. Pharmacol. exp. Ther.143, 169–173 (1964).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pearl, J., Michel, C.R. & Bohnet, E.A. Effects of morphine and nalorphine on the phenylquinone-induced syndrome in monkeys. Psychopharmacologia 14, 266–270 (1969). https://doi.org/10.1007/BF02190111

Download citation

Key-Words

  • Monkeys
  • Phenyl-p-quinone
  • Analgesics
  • Morphine
  • Nalorphine