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Journal of Applied Phycology

, Volume 8, Issue 2, pp 155–161 | Cite as

Annual variation in composition andin vitro anti-HIV-1 activity of the sulfated glucuronogalactan fromSchizymenia dubyi (Rhodophyta, Gigartinales)

  • N. Bourgougnon
  • M. Lahaye
  • B. Quemener
  • J-C Chermann
  • M. Rimbert
  • M. Cormaci
  • G. Furnari
  • J-M Kornprobst
Article

Abstract

An account is given of the annual variation in composition andin vitro anti-HIV-1 activity of the water-soluble sulfated glucuronogalactan fromSchizymenia dubyi collected in Sicily. No marked variation seasonal chemical or physico-chemical features was observed, with the exception of L-galactose residues and viscosity. Evaluation of the anti-HIV-1 effect of the polysaccharide indicated that syncitial formation and HIV-associated reverse transcriptasein vitro were completely suppressed at 5 μg ml−1 by alga collected during the summer/spring period. This high anti-HIV-1 activity corresponded with a decrease in L-galactose, viscosity and sulfate content of the polysaccharide.

Key words

Schizymenia dubyi sulfated polysaccharide antiviral HIV-1 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • N. Bourgougnon
    • 1
  • M. Lahaye
    • 2
  • B. Quemener
    • 2
  • J-C Chermann
    • 3
  • M. Rimbert
    • 4
  • M. Cormaci
    • 5
  • G. Furnari
    • 5
  • J-M Kornprobst
    • 4
  1. 1.Laboratoire de Biologie et Biochimie MarinesPôle Sciences et Technologie, Université de La RochelleLa RochelleFrance
  2. 2.Laboratoire de Biochimie et Technologie des Glucides, INRANantes Cedex 03France
  3. 3.INSERM U322, Campus Universitaire de Luminy BP33Marseille Cedex 09France
  4. 4.ISOMer, Faculté de PharmacieNantes, Cedex 01France
  5. 5.Dipartimento di BotanicaUniversità di CataniaSicilyItaly

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