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Journal of Applied Phycology

, Volume 6, Issue 2, pp 159–176 | Cite as

Structure and biosynthesis of toxins from blue-green algae (cyanobacteria)

  • Kenneth L. Rinehart
  • Michio Namikoshi
  • Byoung W. Choi
Article

Abstract

Microcystis andNodularia species produce cyclic hepta- and pentapeptides, microcystins and nodularin, respectively, both containing the same unusual C20 amino acid, abbreviated Adda. Biosynthesis of nodularin fromNodularia and especially of Adda employs a pathway similar to that employed byMicrocystis for producting microcystins. Nearly 30 new microcystins have been isolated in our laboratory from cyanobacteria species and their structures assigned, largely employing tandem FAB mass spectrometry (FABMS/CID/MS). Acyclic peptides, some of them presumed precursors of nodularin and microcystins, have now been isolated and characterized. The numerous analogs identified or synthesized allow the identification of important parameters in a structure-activity relationship study.

Key words

cyanobacterial toxins biosynthesis nodularin microcystins protein phosphatases stucture assignment mass spectrometry metabolism 

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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Kenneth L. Rinehart
    • 1
  • Michio Namikoshi
    • 1
  • Byoung W. Choi
    • 1
  1. 1.Roger Adams LaboratoryUniversity of IllinoisUrbanaUSA

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