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Human Genetics

, Volume 97, Issue 3, pp 369–374 | Cite as

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

  • Alexandra I. F. Blakemore
  • Angela Cox
  • Ana-Maria Gonzalez
  • Joanna K. Maskill
  • Marianne E. Hughes
  • R. Malcolm Wilson
  • John D. Ward
  • Gordon W. Duff
Original Investigation

Abstract

We have previously found association between an allele of the interleukin-1 (IL-1) receptor antagonist gene (ILIRN) and several inflammatory diseases, where IL-1 has been implicated in the inflammatory mechanism. We have now, therefore, tested the association of this specific allele (ILIRN*2) with complications of diabetes which have an inflammatory tissue component. We have tested the allele frequency of ILIRN*2 in 128 patients with insulin-dependent and 125 with non-insulin-dependent diabetes mellitus (NIDDM). There was a significant association between carriage of ILIRN*2 and diabetic nephropathy (P < 0.0001,Pcorrected < 0.0012). The association was significant in both types of diabetes, but the observed increase was highest in NIDDM, rising to double the control levels. It appears that ILIRN*2 is a novel genetic marker of severity of inflammatory complications of diseases rather than a marker of disease susceptibility. If the DNA polymorphism is associated with altered gene function, new therapeutic interventions may be possible.

Keywords

Diabetes Mellitus Receptor Antagonist Allele Frequency Inflammatory Disease Diabetic Nephropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Alexandra I. F. Blakemore
    • 1
  • Angela Cox
    • 1
  • Ana-Maria Gonzalez
    • 1
  • Joanna K. Maskill
    • 1
  • Marianne E. Hughes
    • 2
  • R. Malcolm Wilson
    • 2
  • John D. Ward
    • 2
  • Gordon W. Duff
    • 1
  1. 1.Section of Molecular Medicine, Department of MedicineUniversity of Sheffield, Royal Hallamshire HospitalSheffieldUK
  2. 2.Diabetes CentreRoyal Hallamshire HospitalSheffieldUK

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