The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
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The aim of this study was to explore, in a large and non-censored twin cohort, the nature (i.e., additive versus non-additive) and magnitude (i.e., heritability) of genetic influences on inter-individual differences in human longevity. The sample comprised all identified and traced non-emigrant like-sex twin pairs born in Denmark during the period 1870–1900 with a zygosity diagnosis and both members of the pairs surviving the age of 15 years. A total of 2872 pairs were included. Age at death was obtained from the Danish Central Person Register, the Danish Cause-of-Death Register and various other registers. The sample was almost non-censored on the date of the last follow-up (May 1, 1994), all but 0.6% had died, leaving a total of 2872 pairs for analysis. Proportions of variance attributable to genetic and environmental factors were assessed from variance-covariance matrices using the structural equation model approach. The most parsimonious explanation of the data was provided by a model that included genetic dominance (non-additive genetic effects caused by interaction within gene loci) and non-shared environmental factors (environmental factors that are individual-specific and not shared in a family). The heritability of longevity was estimated to be 0.26 for males and 0.23 for females. The small sex-difference was caused by a greater impact of non-shared environmental factors in the females. Heritability was found to be constant over the three 10-year birth cohorts included. Thus, longevity seems to be only moderately heritable. The nature of genetic influences on longevity is probably non-additive and environmental influences non-shared. There is no evidence for an impact of shared (family) environment.
KeywordsStructural Equation Model Genetic Influence Twin Pair Parsimonious Explanation Human Longevity
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- Fisher RA (1930) The genetical theory of natural selection. Clarendon, OxfordGoogle Scholar
- Hauge M, Harvald B, Fischer M, Gotlieb-Jensen N, Juel-Nielsen N, Raebild I, et al (1968) The Danish Twin Register. Acta Genet Med Gemellol (Roma) 2:315–331Google Scholar
- Hauge M (1981) The Danish twin register. In: Mednick SA, Baert AE, Bachmann BP (eds) Prospective longitudinal research. Oxford Medical, Oxford, pp 217–222Google Scholar
- Holm NV (1983) The use of twin studies to investigate causes of diseases with complex etiology with a focus on cancer (in Danish). Thesis, Odense University, OdenseGoogle Scholar
- Lykken DT, McGue M, Tellegen A, Bouchard TJ (1993) Emergenesis. Genetic traits that may not run in families. Am Psychol 47:1565–1577Google Scholar
- Mayer PJ (1991) Inheritance of longevity evinces no secular trend among members of six New England families born 1650–1874. Am J Hum Biol 3:49–58Google Scholar
- Neale MC, Cardon LR (1992) Methodology for genetic studies of twins and families, 1st edn. Kluwer, DordrechtGoogle Scholar
- Neale MC (1994) Mx: statistical modeling, 2nd edn. Department of Psychiatry, Box 710 MCV, Richmond, VA 23298, USAGoogle Scholar
- Pearl R (1931) Studies on human longevity. IV. The inheritance of longevity. Hum Biol 3:245–269Google Scholar