Molecular studies of the aetiology of trisomy 8 in spontaneous abortions and the liveborn population
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We have determined the parental origin in eight cases of constitutional trisomy 8. In all four cases of spontaneous abortion, the additional chromosome was maternal in origin and there was evidence for nullichiasmate meiosis I occurring in the genesis of this trisomy. In contrast, all four cases of liveborn trisomy 8 appear to have arisen by a mechanism consistent with the post-zygotic mitotic gain of the additional chromosome.
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- Hassold TJ, Merrill M, Adkins K, Freeman S, Sherman S (1995) Recombination and maternal age-dependent non-disjunction: molecular studies of trisomy 16. Am J Hum Genet 67: 867–874Google Scholar
- Jacobs PA, Hassold TJ (1995) The origin of numerical chromosome abnormalities. In: Hall J, Dunlap J (eds) Advances in genetics, vol. 33. Academic Press, New York, pp 101–133Google Scholar
- Polymeropoulos MH, Xiao H, Merril CR (1992) Dinucleotide repeat polymorphism at the human c-myc oncogene locus (MYC). Hum Mol Genet 1:65–65Google Scholar
- Riccardi VM (1977) Trisomy 8: an international study of 70 patients. Birth Defects 13:171–184Google Scholar