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Structural alterations and content of nicotinamide-adenine nucleotides in skeletal muscle of rat in chronic experimental carbon disulfide intoxication

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The histological nature and extent of muscular lesions and the content of nicotinamide-adenine nucleotides in the skeletal muscles of white rats exposed to CS2 at a concentration of 1.5 mg/l for 1 to 14 months were studied.

From the 5th month of exposure muscle atrophy of the denervation type was the constant histological finding. Five months later a significant fall in the nucleotide level was noted, parallel to apparent paresis of the hind limbs and gross muscular atrophy. No evidence of any inflammatory reaction or dystrophic myopathy was found. Reduction of the nucleotide content was attributed therefore to secondary alterations in the metabolism of skeletal muscle undergoing atrophy.

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This investigation has been done under the Polish-American agreement

This investigation has been done under the Polish-American agreement

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Wrońska-Nofer, T., Stetkiewicz, J. & Szendzikowski, S. Structural alterations and content of nicotinamide-adenine nucleotides in skeletal muscle of rat in chronic experimental carbon disulfide intoxication. Int. Arch. Arbeitsmed 31, 123–134 (1973). https://doi.org/10.1007/BF02178950

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Key words

  • Carbon disulfide
  • Rat muscle alterations