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Pharmacy World and Science

, Volume 16, Issue 6, pp 360–364 | Cite as

Stability of an oral midazolam solution for premedication in paediatric patients

  • D. Soy
  • M. C. Lopez
  • L. Salvador
  • L. Parra
  • M. Roca
  • E. Chabas
  • C. Codina
  • P. Modamio
  • E. L. Mariño
  • J. Ribas
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Abstract

The objectives of this study were to assess the stability of a 1 mg/ml oral midazolam solution elaborated by our Hospital Pharmacy Service, and to confirm its clinical elfect in presurgical paediatric patients. The solution's stability was tested by determining its pH and its UV-visible absorption spectrum at room temperature for up to 60 days. A high performance liquid chromatography method was used to confirm it. There was no significant change in pH value of either the test or a control solution. No loss of midazolam could be detected during the test. The Anaesthesiology Service assessed the sedation quality (very good, good, bad) and the venous puncture response, 20 minutes afier the administration of 0.3 mg/kg of an oral midazolam solution. Twenty children were examined (age: 4–7 years). In addition, the hacmodynamic and ventilatory functions were evaluated.

Keywords

Drug compounding Drug stability Midazolam/administration and dosage Pediatrics 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1994

Authors and Affiliations

  • D. Soy
    • 1
  • M. C. Lopez
    • 1
  • L. Salvador
    • 2
  • L. Parra
    • 2
  • M. Roca
    • 1
  • E. Chabas
    • 2
  • C. Codina
    • 1
  • P. Modamio
    • 1
  • E. L. Mariño
    • 1
  • J. Ribas
    • 1
  1. 1.Pharmacy Service, Department of Pharmacy, Hospital Clínic i ProvincialUniversity of BarcelonaBarcelonaSpain
  2. 2.Anesthesiology Service, Hospital Clínic i ProvincialUniversity of BarcelonaBarcelonaSpain

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