Activation products can be elicited from zymosan suspended in fresh serum. However, variations in experimental conditions modify dramatically the ability of serumtreated zymosan to modulate polymorphonuclear cell (PMN) adhesiveness. Indeed, serum treated by small amounts of zymosan reduces while large amounts enhance adhesiveness. When zymosan is boiled, smaller quantities are needed to obtain an effect similar to large ones.
Therefore, we can propose that not a unique factor like C5a but different activation products for PMN are elicited during treatment of serum by zymosan.
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Appelboom, T., Delronche, M., Pierart, M. et al. Diverging effects of activated serum on polymorphonuclear cell adherence. Agents and Actions 13, 439–441 (1983). https://doi.org/10.1007/BF02176413
- Cell Adherence
- Activation Product
- Unique Factor
- Polymorphonuclear Cell
- Diverge Effect