Diverging effects of activated serum on polymorphonuclear cell adherence
The Complement System: Formation, Activation and Modes of Action
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Abstract
Activation products can be elicited from zymosan suspended in fresh serum. However, variations in experimental conditions modify dramatically the ability of serumtreated zymosan to modulate polymorphonuclear cell (PMN) adhesiveness. Indeed, serum treated by small amounts of zymosan reduces while large amounts enhance adhesiveness. When zymosan is boiled, smaller quantities are needed to obtain an effect similar to large ones.
Therefore, we can propose that not a unique factor like C5a but different activation products for PMN are elicited during treatment of serum by zymosan.
Keywords
Cell Adherence Activation Product Unique Factor Polymorphonuclear Cell Diverge Effect
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
- [1]P.R. Craddock, D. Hammerschmidt, J.G. White, A.P. Dalmasso andH.S. Jacob,Complement (C5a)induced granulocyte aggregation in vitro, J. clin. Invest.60, 260–264 (1977).Google Scholar
- [2]J. Fehr andH.S. Jacob,In vitro granulocyte adherence and in vivo margination, J. exp. Med.146, 641–652 (1977).Google Scholar
- [3]H.S. Jacob, P.R. Craddock, D.E. Hammerschmidt andC. Moldow,Complement-induced granulocyte aggregation, New Engl. J. Med.302, 789–794 (1980).Google Scholar
- [4]J.M. Harlan, P.D. Killen L.A. Harker andG.E. Striker,Neutrophil-mediated endothelial injury in vitro: mechanisms of cell detachment, J. clin. Invest.68, 1394–1403 (1981).Google Scholar
- [5]T. Appelboom, A. Govaerts andJ. Wybran,The leukocyte adherence inhibition test in arthritis, Lancetii, 65–68 (1978).Google Scholar
- [6]T. Appelboom, N. Dourov, R. Görtz andJ. Wybran,Leukocyte adherence inhibition test: cellular requirements for the elaboration of a PMN adherence inhibition activity, Clin. Immunopathol.20, 63–70 (1981).Google Scholar
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© Birkhäuser Verlag 1983