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Autoregulation of ocular blood flow during changes in intraocular pressure

Preliminary results
  • L. E. Pillunat
  • R. Stodtmeister
  • I. Wilmanns
  • Th. Christ
Article

Abstract

Visual evoked potentials were recorded in six normal subjects and in three patients with primary open-angle glaucoma, while intraocular pressure was artificially elevated in stepwise increases. The resulting perfusion-pressure amplitude curves in our controls showed a kink, which can be interpreted as a sign of vascular autoregulation. No kink was observed in the curves of our glaucoma patients, which we interpret as indicating a lack of vascular autoregulation in primary open-angle glaucoma.

Keywords

Public Health Blood Flow Glaucoma Intraocular Pressure Glaucoma Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alm A, Bill A (1972) The oxygen supply to the retina. II. Effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. Acta Physiol Scand 84: 306Google Scholar
  2. Alm A, Bill A (1973) Ocular and optic nerve blood flow at normal and increased intra-ocular pressures in monkeys. Exp Eye Res 15: 15Google Scholar
  3. Anderson DR, Davis EB (1974) Retina and optic nerve after posterior ciliary artery occlusion. An experimental study in squirrel monkeys. Arch Ophthalmol 92: 422Google Scholar
  4. Bartl G (1978) Das Elektroretinogramm und das evozierte Sehrindenpotential bei normalen und an Glaukom erkrankten Augen. Grafes's Archive Clin Exp Ophthalmol 207: 243Google Scholar
  5. Gafner F, Goldmann H (1955) Experimentelle Untersuchungen über den Zusammenhang von Augendrucksteigerungen und Gesichtsfeldschädigung. Ophthalmologica 130: 357Google Scholar
  6. Gee W, Oiler DW, Wylie EJ (1976) Noninvasive diagnosis of carotid occlusion by ocular pneumoplethysmography. Stroke 7: 18Google Scholar
  7. Hayatsu H (1964a) Measurement of blood pressure in retina, expecially on calibration curves for Mikuni's ophthalmodynamometer. I. Calibration curves by Schiötz's standardized tonometer. Acta Soc Ophthalmol Jpn 68: 111Google Scholar
  8. Hayatsu H (1964b) Measurement of blood pressure in retina, especially on calibration curves for Mikuni's ophthalmodynamometer. II. Calibration curves by Goldmann's applanation tonometer. Acta Soc Ophthalmol Jpn 68: 175Google Scholar
  9. Hayatsu H (1964c) Measurements of blood pressure in retina, especially on calibration curves for Mikuni's ophthalmodynamometer. III. Influences of age, refraction and ocular rigidity upon calibration curves. Acta Soc Ophthalmol Jpn 68: 1289Google Scholar
  10. Hayreh SS (1963) The central artery of the retina. Its role in the blood supply of the optic nerve. Br J Ophthalmol 47: 651Google Scholar
  11. Hayreh SS (1978) Glacuoma damage — pathogenesis of optic nerve damage and visual field defects. In: Heilmann K, Richardson KT (eds) Glaucoma. Conseptions of a disease. Thieme, Stuttgart, pp 104–137Google Scholar
  12. Mikuni M, Iwata K (1965) Mikuni's ophthalmodynamometer. Acta Med Biol 12: 279Google Scholar
  13. Padmos P, van Norren D (1972) the vector voltameter as a tool to measure electroretinogram spectral sensitivity and dark adaptation. Invest Ophthalmol 11: 783–788Google Scholar
  14. Robert Y, Maurer W (1984) Pallor of the optic disc in glaucoma patients with artificial hypertension. Doc Ophthalmol 57: 203Google Scholar
  15. Robert Y, Niesl P, Ehrengruber H (1982) Measurements of the optical density of the optic nerve head. II. Short-time fluctuations of the optical density of the nerve head. Graefe's Archive Clin Exp Ophthalmol 219: 183Google Scholar
  16. Ulrich WD, Ulrich CH (1984a) An electrophysiological approach to the diagnosis and treatment of glaucoma. Dev Ophthalmol 9: 140Google Scholar
  17. Ulrich WD, Ulrich CH (1984b) Okulooszillodynamographie, ein neues Untersuchungsverfahren zur Bestimmung des Ophthalmicadruckes und zur okulären Pulskurvenanalyse. Paper presented in Vienna at the 20th Convention of the Austrian Ophthalmological Society, 1984. Klin Monatsbl Augenheilkd (in press)Google Scholar
  18. Wilmanns I, Stodtmeister R (1977) Ein neues Verfahren zur Kalibrierung elektrophysiologischer Untersuchungseinheiten. Graefe's Arch Clin Exp Ophthalmol 205: 33Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • L. E. Pillunat
    • 1
  • R. Stodtmeister
    • 1
  • I. Wilmanns
    • 2
  • Th. Christ
    • 1
  1. 1.Universitäts-AugenklinikUlm/DonauFederal Republic of Germany
  2. 2.Universitäts-AugenklinikBonnFederal Republic of Germany

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