Molecular and General Genetics MGG

, Volume 252, Issue 3, pp 223–229 | Cite as

bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein inNeurospora crassa

  • J. J. P. Bruchez
  • J. Eberle
  • W. Kohler
  • V. Kruft
  • A. Radford
  • V. E. A. Russo
Original Paper


Blue light plays an important role in developmental control throughout nature. Thebli-4 gene ofNeurospora crassa, together withbli-3, al-1 andal-2, is rapidly inducible by blue light. Induction leads to a ninety-fold increase in transcription rate over the dark control level, and the gene therefore appears to be of prime importance in the blue-light induction pathway ofN. crassa. We describe the sequencing and analysis ofbli-4 and the 38 kDa protein it encodes. We show that the protein is very rapidly imported into the mitochondria and exhibits high homology with the family of short-chain alcohol dehydrogenases.

Key words

Neurospora crassa Blue light Mitochondria Short-chain alcohol dehydrogenase 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. J. P. Bruchez
    • 1
  • J. Eberle
    • 1
  • W. Kohler
    • 1
  • V. Kruft
    • 1
  • A. Radford
    • 1
  • V. E. A. Russo
    • 1
  1. 1.Max-Planck-Institut für molekulare GenetikBerlinGermany

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