Proteins of the extracellular matrix in vitreoretinal membranes

  • O. F. Scheiffarth
  • A. Kampik
  • H. Günther
  • K. von der Mark
Laboratory Investigations


Epiretinal and vitreous membranes of different etiology, e.g., in diabetic retinopathy, following retinal detachment, trauma or inflammatory processes, show a similar morphology. The exact composition of the extracellular matrix and the pathogenesis of these membranes remain uncertain. The presence of collagens, type I-IV, laminin, and fibronectin can be shown by means of immunofluorescence with affinity-purified antibodies. Collagen type V was revealed by SDS-polyacrylamide-gel electrophoresis. These proteins of the extracellular matrix have diverse properties and functions in the membranes, as is discussed. Despite great similarities in morphology, there are some differences in the matrix, seemingly dependent upon the etiology of the membrane.


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • O. F. Scheiffarth
    • 1
  • A. Kampik
    • 1
  • H. Günther
    • 1
  • K. von der Mark
    • 2
  1. 1.Universitäts-AugenklinikMünchen 2Federal Republic of Germany
  2. 2.Max-Planck-Institut für BiochemieMartinsriedFederal Republic of Germany

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