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Ecotin: A most adaptable protease inhibitor

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Summary

Ecotin, a recently discovered protease inhibitor fromE. coli, inhibits virtually all serine proteases in the chymotrypsin superfamily. X-ray structures and mutational analysis show how pan-inhibition relates to structure and flexibility.

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Correspondence to Robert J. Fletterick.

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Gillmor, S.A., McGrath, M.E. & Fletterick, R.J. Ecotin: A most adaptable protease inhibitor. Perspectives in Drug Discovery and Design 2, 475–482 (1995). https://doi.org/10.1007/BF02172039

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Key words

  • Serine protease
  • Conformational change
  • E. coli