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Perspectives in Drug Discovery and Design

, Volume 2, Issue 3, pp 445–458 | Cite as

Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction

  • Jan Potempa
  • Robert Pike
  • Jim Travis
Perspectives Part II. Viral, Parasitic And Microbial Proteases

Summary

Periodontitis is an excellent model of local tissue destruction due to the uncontrolled action of host and microbial proteinases. Although host enzymes are responsible for direct degradation of connective tissue, proteinases from the periodontopathogenic bacteriumPorphyromonas gingivalis are able to activate the kallikrein/kinin cascade, disrupt coagulation, and activate complement-mediated chemotaxis. Since the hallmarks of adult onset of periodontitis include infection by this pathogen, bleeding, increased crevicular flow, and neutrophil accumulation, investigations of this disease at a biochemical level indicate a major role for bacterial proteinases in infections byP. gingivalis.

Key words

Proteolytic enzymes Gingipain Periodontal diseases Bacterial infection Inflammation 

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Copyright information

© ESCOM Science Publishers B.V. 1995

Authors and Affiliations

  • Jan Potempa
    • 1
  • Robert Pike
    • 2
  • Jim Travis
    • 3
  1. 1.Department of Microbiology and Immunology, Institute of Molecular BiologyJagiellonian UniversityKrakówPoland
  2. 2.Biochemistry DepartmentUniversity of NatalScottsvilleSouth Africa
  3. 3.Department of Biochemistry and Molecular BiologyUniversity of GeorgiaAthensU.S.A.

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