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Blood-retinal and blood-aqueous barrier permeability, lens autofluorescence and transmission in insulin-dependent diabetic youngsters

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The permeability of the blood aqueous and blood retinal barrier, the lens transmission, and the lens autofluorescence were measured by fluorophotometry in 7 diabetic youngsters treated by conventional therapy (mean age, 10.9 ± 4.4 years), 9 diabetic youngsters treated by continuous s.c. insulin infusion (mean age, 12.3 ± 5.0 years), and 13 healthy controls (mean age, 12.4 ± 5.1 years). The mean permeability value for the blood retinal barrier of the diabetic juveniles did not differ significantly from that of the controls (P > 0.4), and no correlation with metabolic control (HbAlc) or duration of diabetes was found (P > 0.1). No differences in lens transmission larger than 4% were found. The mean value of lens autofluorescence corrected for normal age-dependency was found to correlate with the metabolic control: an increase of mean HbAlc by 1% resulted in an extra increase of autofluorescence by 11% (P = 0.002). This result suggests that good metabolic control can suppress excess lens autofluorescence, a precursor of cataract.

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Correspondence to Els van Wirdum.

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Supported by the Diabetes Fonds Nederland, the Stichting Blindenpenning, the Stichting Vrienden van het Oogziekenhuis, and the Stichting Blindenhulp

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van Wirdum, E., van Best, J., Bruining, G.J. et al. Blood-retinal and blood-aqueous barrier permeability, lens autofluorescence and transmission in insulin-dependent diabetic youngsters. Graefe's Arch Clin Exp Ophthalmol 227, 26–29 (1989). https://doi.org/10.1007/BF02169820

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  • Public Health
  • Permeability
  • Cataract
  • Metabolic Control
  • Conventional Therapy