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Effetto del 17-Idrossi 11-Deidrocorticosterone (Cortisone) sulla Granulomatosi coccidioide sperimentale

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The effect of 17-hydroxy-11-dehydrocorticosterone (Cortisone), 11-desoxycorticosterone (DCA), 21-acetoxy-pregnenolone (Artisone) on experimental Coccidioidal granuloma of the Rat has been investigated.

While in controls, in DCA- and Artisone-treated animals the infection remained localized, 3 out of 5 Cortisone-treated rats presented a diffusion of the pathological process to the spleen and the lungs. Histologically: in the control animals there was a profuse growth of all elements of new connective tissue; in the DCA-and Artisone-treated rats a slight reduction of connective elements was observed; in Cortisone-treated rats the production of connective elements was strongly inhibited.

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Redaelli, P., Cavallero, C., Borasi, M. et al. Effetto del 17-Idrossi 11-Deidrocorticosterone (Cortisone) sulla Granulomatosi coccidioide sperimentale. Experientia 7, 108–109 (1951). https://doi.org/10.1007/BF02165565

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