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A rapid and high-yield aqueous phase preparation procedure for123I-labelled meta-iodobenzylguanidine

Abstract

A new, aqueous phase preparation procedure for123I-mIBG /meta-iodobenzylguanidine/ is described. It comprises a copper-catalyzed exchange reaction between aqueous123I-iodide and mIBG at 150 °C for 45 min, a purification via anion-exchange chromatography, and a sterilization via micropore filtration. Overall preparative yield, radiochemical purity and specific activity amount to >90%, >99.7% and >1015 Bq.mol−1 mIBG, respectively. Other features are simplicity /no evaporation of water or other solvents/, reproducibility of labelling yield and radiochemical purity, and speed /total time required 1.5 h/.

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van Doremalen, P.A.P.M., Janssen, A.G.M. A rapid and high-yield aqueous phase preparation procedure for123I-labelled meta-iodobenzylguanidine. Journal of Radioanalytical and Nuclear Chemistry Letters 96, 97–103 (1985). https://doi.org/10.1007/BF02163075

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Keywords

  • Chromatography
  • Physical Chemistry
  • Purification
  • Evaporation
  • Filtration