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Produktion von Acetylmethylkarbinol durch Aktinomyzeten

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The production of acetylmethylcarbinol by various strains of actinomycetes was established. The biosynthesis of acetylmethylcarbinol depends largely on the composition of the fermentation medium and on the presence of arsenite, which regulates the metabolism of pyruvic acid. In the case ofStreptomyces aureofaciens the stimulating effect of phosphate on the production of acetylmethylcarbinol gives a partial explanation of the well-known negative effect of phosphate on the biosynthesis of chlortetracycline.

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  1. 1

    V. Musílek undV. Ševčík, Naturwissenschaften45, 215 (1958).

  2. 2

    V. Musílek undV. Ševčík, Naturwissenschaften45, 215 (1958);45, 86 (1958); Čs. mikrobiologie3, 205 (1958).

  3. 3

    G. Biffi, G. Boretti, A. di Marco undP. Pennella, Appl. Microbiol.2, 288 (1954).

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Musílek, V., Ševčík, V., Musílková, M. et al. Produktion von Acetylmethylkarbinol durch Aktinomyzeten. Experientia 14, 323–324 (1958). https://doi.org/10.1007/BF02160386

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  • Phosphate
  • Fermentation
  • Arsenite
  • Fermentation Medium
  • Pyruvic Acid