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Vorkommen und Bedeutung des körpereigenen Heparins

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Summary

The chemistry of heparin and its occurrence in the organism are briefly explained. Heparin is mainly found in theEhrlich tissue-mastcells. Their anatomy, topography, physiology, pathology and pathophysiology are dealt with in detail. The mastcells are experimentally established to be the place where heparin is formed and stored. It is now being experimentally and clinically investigated whether and to what extent naturally occuring heparin possesses a function which goes beyond that of a physiological anticoagulant and whether it is of any significance as a growth-inhibitor of tumors. It is further being examined whether naturally occuring heparin has an influence on the formation of connective-tissue groundsubstance and whether it may have an effect on the inhibition of arteriosclerotic vascular changes. The interpretation of these investigations, however, is still more or less speculative.

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References

  1. 2

    P. Ehrlich, Arch. Mikroskop. Anat.13, 263 (1877).

  2. 3

    J. E. Jorpes, H. Holmgren undO. Wilander, Z. mikroskop. anat. Forschg.42, 279 (1937).

  3. 4

    J. McLean, Amer. J. Physiol.41, 250 (1916).

  4. 5

    W. H. Howell, Amer. J. Physiol.71, 553 (1924/25).

  5. 6

    J. E. Jorpes,Heparin in the treatment of thrombosis (Oxford Univ. Press, Geoffrey Cumberlege, London 1946).

  6. 7

    M. L. Wolfrom undF. A. Rice, J. Amer. Chem. Soc.68, 532 (1946).

  7. 8

    J. E. Jorpes undS. Gardell, J. Biol. Chem.176, 267 (1948).

  8. 9

    L. B. Jaques, E. T. Walters undA. F. Charles, J. Biol. Chem.144, 229 (1942).

  9. 10

    R. Marbet undA. Winterstein, Exper.8, 41 (1952).

  10. 1

    O. Schmiedeberg, Arch. exp. Path. Pharm.28, 355 (1891).

  11. 2

    R. Marbet undA. Winterstein, Exper.8, 41 (1952).

  12. 3

    R. Jensen, O. Snellmann undB. Sylvén, J. Biol. Chem.174, 265 (1948).

  13. 4

    A. Winterstein, inF. Ullmann,Encyklopädie der technischen Chemie, 3. Aufl. 4. Bd. (Verlag Urban und Schwarzenberg, München und Berlin, im Druck).

  14. 5

    L. Lison, C. r. Soc. Biol.118, 821 (1935); Arch. de Biol.46, 599 (1935).

  15. 6(a)

    J. E. Jorpes,Heparin in the treatment of thrombosis (Oxford Univ. Press, Geoffrey Cumberlege, London 1946).

  16. 7

    P. Ehrlich, Arch. Mikroskop. Anat.13, 263 (1877).

  17. 8

    K. Hiruma, Biochem. Z.139, 152 (1923).

  18. 9

    H. J. Holmgren, Acta Anat.2, 40 (1946/47).

  19. 1

    J. E. Jorpes, H. Holmgren undO. Wilander, Z. mikroskop. anat. Forschg.42, 279 (1937).

  20. 2

    U. Friberg, W. Graf undB. Aberg, Acta Pathol. Microbiol. Scand.29, 197 (1951).

  21. 3

    Ch. Julén, O. Snellmann undB. Sylvén, Acta physiol. Scand.19, 289 (1950).

  22. 4

    H. U. Zollinger, Exper.6, 384 (1950).

  23. 5

    M. Staemmler, Frankfurter Z. Pathol.25, 391 (1921).

  24. 6

    U. Quensel, Acta Pathol. Microbiol. Scand. Suppl.16, 358 (1933).

  25. 7

    E. Brach, Folia Haematol.31, 202 (1925).

  26. 8

    J. R. McDonald, Arch. Pathol.45, 622 (1948).

  27. 9

    F. Bloom, Arch. Pathol.33, 661 (1942).

  28. 10

    H. Hauser, Exper.4, 197 (1948).

  29. 1

    J. Oliver, F. Bloom undC. Mangieri, J. exper. Med.86, 107 (1947).

  30. 2

    M. Staemmler, Frankfurter Z. Pathol.25, 391 (1921).

  31. 3

    P. Ehrlich, Arch. Mikroskop. Anat.13, 263 (1877).

  32. 4

    J. E. Jorpes,Heparin in the treatment of thrombosis (Oxford Univ. Press, Geoffrey Cumberlege, London 1946).

  33. 5

    J. R. Prakken undM. J. Woerdeman, Dermatologica105, 116 (1952).

  34. 6

    W. E. Ehrich, J. Seifter, H. E. Alburn undA. J. Begany, Proc. Soc. Exp. Biol. Med.70, 183 (1949).

  35. 7

    G. T. Williams, Amer. J. Clin. Pathol.22, 1039 (1952).

  36. 8

    M. Rattezzatti, Presse Médicale59, 1628 (1951).

  37. 1

    O. Wilander, Scand. Arch. Physiol.81, Suppl. 15 (1938).

  38. 2

    J. G. Allen undL. O. Jacobson, Science105, 388 (1947).

  39. 3

    H. St. Stender, O. Elbert undW. Sohre, Klin. Wschr.1952, 1021.

  40. 4

    R. Harma undP. Suomalainen, Acta physiol. Scand.24, 90 (1951).

  41. 5

    R. Frick, Acta Haematol.4, 97 (1950).

  42. 6

    W. Schürer, Helv. med. Acta13, 328 (1946).

  43. 7

    J. Myslivecek, C. r. Soc. Biol.142, 1041 (1948).

  44. 8

    E. Baeckeland, C. r. Soc. Biol.144, 1005, 1007 (1950).

  45. 9

    J. E. Jorpes, H. Holmgren undO. Wilander, Z. mikroskop. anat. Forschg.42, 279 (1937).

  46. 1

    A. Fischer, Protoplasma26, 344 (1936).

  47. 2

    A. Balazs undH. Holmgren, Proc. Soc. Exp. Biol. Med.72, 142 (1949).

  48. 3

    G. H. Pfaff, F. Bloom undC. Reilly, Exp. Med.86, 117 (1947).

  49. 4

    L. V. Heilbrunn undU. L. Wilson, Proc. Soc. Exp. Biol. Med.70, 179 (1949).

  50. 5

    H. T. Schreuss, Dermatol. Z.40, 9 (1924).

  51. 6

    R. Roca de Vinyals, C. r. Soc. Biol.108, 177 (1931).

  52. 7

    W. Cramer undW. L. Simpson, Cancer Res.4, 601 (1944).

  53. 8

    H. J. Holmgren undG. Wohlfahrt, Cancer Res.7, 686 1947).

  54. 1

    N. S. Olsen undR. O. Smith, Amer. J. Physiol.159, 583 (1949).

  55. 2

    L. G. Larsson undB. Sylvén, Cancer Res.7, 676, 680 (1947);8, 449 (1948).

  56. 3

    G. Asboe-Hansen, Bull. Hist. appl. Physiol.27, 5 (1950).

  57. 4

    Marchand, zitiert inM. Staemmler, Frankfurter Z. Pathol.25, 391 (1921).

  58. 5

    Maximow, zitiert inM. Staemmler, Frankfurter Z. Pathol.25, 391 (1921).

  59. 6

    M. Staemmler, Frankfurter Z. Pathol.25, 391 (1921).

  60. 7

    K. Meyer, Amer. J. Med.1, 676 (1946).

  61. 8

    B. Sylvén, Acta Chir. Scand.86, Suppl. 66 (1941).

  62. 9

    S. H. Bensley, Ann. New York Acad. Sci.52, 983 (1950).

  63. 10

    T. G. Morrione, J. Exp. Med.96, 107 (1952).

  64. 1

    H. Engelberg, Amer. J. Med. Sci.224, 487 (1952).

  65. 1a

    H. Engelberg undT. B. Massell, Amer. J. Med. Sci.225, 14 (1953).

  66. 2

    S. H. Rinzler, J. Travell, H. Bakst, Z. H. Benjamin, R. L. Rosenthal, S. Rosenfeld undB. B. Hirsch, Federat. Proc.12, 361 (1953).

  67. 3

    H. Engelberg, Amer. J. Med. Sci.224, 487 (1952).

  68. 3a

    H. Engelberg undT. B. Massell, Amer. J. Med. Sci.225, 14 (1953).

  69. 4

    P. F. Hahn, Science98, 19 (1943).

  70. 5

    J. W. Gofman, H. B. Jones, F. T. Lindgren, T. P. Lyon, H. A. Elliott undB. Strisower, Circulation2, 161 (1950).

  71. 5a

    J. W. Gofman, F. Lindgren, H. Elliott, W. Manth, J. Hewitt, B. Strisower undV. Herring, Science111, 166, 186 (1950).

  72. 5b

    J. W. Gofman, F. T. Lindgren, H. B. Jones, T. P. Lyon undB. Strisower, J. Gerontology6, 105 (1951).

  73. 5c

    J. W. Gofman et al, Modern Med.1953, 119.

  74. 6

    N. Anitschkow,Arteriosclerosis, byN. Y. Cowdry (Macmillan Company, 1933), 271; Klin. Wschr.4, 2233 (1925).

  75. 1

    A. M. Evans, H. K. Ihrig, J. A. Means, W. Zeit undE. R. Haushalter, Amer. J. Clin. Pathol.22, 354 (1952).

  76. 2

    M. Bevans, J. D. Davidson undF. E. Kendall, Arch. Pathol.51, 288 (1951).

  77. 3

    A. Steiner undF. E. Kendall, Arch. Pathol.42, 433 (1946).

  78. 4

    A. Steiner, F. E. Kendall undM. Bevans, Amer. Heart J.38, 34 (1949).

  79. 4a

    Amer. J. Med.6, 110 (1949).

  80. 5a)

    J. W. Gofman, H. B. Jones, F. T. Lindgren, T. P. Lyon, H. A. Elliott undB. Strisower, Circulation2, 161 (1950).

  81. 5b)

    J. W. Gofman, F. Lindgren, H. Elliott, W. Manth, J. Hewitt, B. Strisower undV. Herring, Science111, 166, 186 (1950).

  82. 5b

    J. W. Gofman, F. T. Lindgren, H. B. Jones, T. P. Lyon undB. Strisower, J. of Gerontology6, 105 (1951).

  83. 5c

    J. W. Gofman et al., Modern Med.1953, 119.

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Studer, A. Vorkommen und Bedeutung des körpereigenen Heparins. Experientia 10, 148–152 (1954). https://doi.org/10.1007/BF02158526

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