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N-Lost- (N-mustard-)Wirkung und chromonemaler Spiralisationsgrad

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Summary

From caryological tests on the lymph nodules punctate during N-mustard cure, it is concluded that the destruction of the resting nuclei without subsequent mitosis is solely responsible for the clinical action. Between N-mustard sensitivity and the condensation or spiralisation grade of the chromosomes, there seems to be an inverse proportionality which explains the special sensitivity of the very early prophase and certain forms of the resting nuclei.

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Grundmann, E. N-Lost- (N-mustard-)Wirkung und chromonemaler Spiralisationsgrad. Experientia 9, 66–68 (1953). https://doi.org/10.1007/BF02155133

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