Experientia

, Volume 23, Issue 9, pp 718–719 | Cite as

Zum Proliferations-Stoffwechsel der Rattenleber nach Teilhepatektomie. Autoradiographische Untersuchungen mit3H-Cytidin,-Phenylalanin und -Thymidin

  • E. Stöcker
  • W. Liebscher
  • H. -W. Altmann
Specialia Chimica. Biochimica
  • 8 Downloads

Summary

During the first wave of parenchymal liver regeneration in adult rats after partial hepatectomy, the cellular synthesis and migration of RNA and the metabolism of protein were studied by autoradiography following an injection of3H-cytidine or3H-l-phenylalanine and double injections of 1 of these precursors +3H-thymidine. The following results were obtained: the synthesis and migration of RNA and the metabolism of protein are enhanced under these conditions of proliferation. In spite of this, the relation of metabolic activity in nucleolus, karyoplasm and cytoplasm remains constant. By double injection techniques it is proved that no differences exist in migration of RNA into the cytoplasm and cytoplasmic protein synthesis between cells with or without DNA synthesizing nuclei.

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References

  1. 2.
    G. Siebert, Verh. dt. Ges. Path.50, 119 (1966).Google Scholar
  2. 3.
    W. Busanny-Caspari undMaria Deimel, Z. ges. exp. Med.136, 456 (1963).PubMedGoogle Scholar
  3. 4.
    H. Rabes, Naturwissenschaften53, 386 (1966).Google Scholar
  4. 5.
    E. Stöcker undW.-D. Heine, Beitr. path. Anat.131, 410 (1965).Google Scholar
  5. 6.
    E. Stöcker, Verh. dt. Ges. Path.50, 53 (1966).Google Scholar
  6. 7.
    H.-W. Altmann, Verh. dt. Ges. Path.50, 15 (1966).Google Scholar
  7. 9.
    I. Liebermann, R. Abrams undP. Ove, J. biol. Chem.238, 2141 (1963).PubMedGoogle Scholar
  8. 10.
    E. W. Taylor, J. Cell Biol.19, 1 (1963); Expl Cell Res.40, 316 (1965).PubMedGoogle Scholar
  9. 11.
    E. Stöcker, W. Liebscher undV. Höper, im Druck.Google Scholar
  10. 12.
    P. Citoler, Karin Citoler, K. Hempel, Brigitte Schultze undW. Maurer, Z. Zellforsch. mikrosk. Anat.70, 419 (1966).PubMedGoogle Scholar
  11. 13.
    R. Baserga, Cancer Res.25, 581 (1965).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1967

Authors and Affiliations

  • E. Stöcker
    • 1
  • W. Liebscher
    • 1
  • H. -W. Altmann
    • 1
  1. 1.Pathologisches Institut der Universität WürzburgDeutschland

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