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Istamina « condizionatore positivo » dell'azione purgativa di alcuni drastici


By the aid of a synthetic antihistaminic drug (dimethylamino-ethyl-benzylaniline) the Authors succeeded in demonstrating that the purgative action of various drastic agents(Oleum Ricini, Elaterium, Colocynthis, Globularia Alypum) is, at least partially, to be accounted to a release of histamine.

Antihistaminic drugs are indeed able, in quantities by themselves ineffective on the alimentary canal, to delay or even to abolish the purgative action of very large doses of the examined drastics.

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Erspamer, V., Paolini, A. Istamina « condizionatore positivo » dell'azione purgativa di alcuni drastici. Experientia 2, 455–458 (1946).

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