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Über den Chemismus von Zustandsänderungen des Aktomyosins

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(1) By means of a simple method the conditions were investigated for contraction and relaxation of actomyosin (AM) under the influence of potassium, magnesium, and calcium ions, of adenosintriphosphate (ATP) or muscle-adenylic-acid and phosphocreatin.

(2) Raising the calcium chloride concentration to 0.2 m and raising thep H from 6.9 to 7.3 hinders the contraction of actomyosin by ATP; in uncontracted AM-gel, ATP leads to a relaxation under these conditions.

(3) Relaxation of the contracted gel can be brought about by dissolving in potassium chloride and precipitating by dilution: calcium furthers this relaxation; afterward ATP leads again to a contraction.

(4) Remainders of ATP from the first contraction lead in this stage again to a partially contracted gel; phosphocreatin reinforces this effect.

(5) Certain SH-groups and amino groups, but not carboxyl groups, are involved in the production of the contraction.

(6) SH- and amino groups are also necessary for the ATP-ase effect. The relation of actomyosin-ATP-ase to contraction, of myosin-ATP-ase to relaxation is pointed out.

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  1. 1

    H. H. Weber, Erg. Physiol.36, 109 (1933).

  2. 2

    A. Szent-Györgyi,Chemistry of Muscular Contraction, Acad. Press., Inc., Publishers, New York, 1947, S. 73.

  3. 4

    F. Buchthal, A. Deutsch, G. G. Knappeis undA. Munch-Petersen, Acta physiol. Scand.16, 326 (1949).

  4. 5

    A. Szent-Györgyi, l.c., S. 36.

  5. 6

    F. Buchthal, A. Deutsch undG. Knappeis, Nature153, 774 (1944).

  6. 1

    M. Dubuisson, Exper.3, 213 (1947); Arch. int. Physiol.50, 203 (1940).

  7. 2

    L. Hahn undG. Hevesy, Acta physiol. Scand.2, 51 (1941).

  8. 2a

    T. Noonan, W. Fenn, L. Haege, Amer. J. Physiol.133, 254 (1941).

  9. 3

    T. P. Singer undE. S. G. Barron, Proc. Soc. Exper. Biol. Med.56, 120 (1944).

  10. 4

    K. Bailey undS. V. Perry, Biochem. et biophys. acta1, 506 (1947).

  11. 5

    R. M. Herriot, M. L. Anson undJ. H. Northrop, J. gen. Physiol.30, 187 (1946).

  12. 1

    A. Szent-Györgyi, l.c., und zwar S. 55.

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Kuschinsky, G., Turba, F. Über den Chemismus von Zustandsänderungen des Aktomyosins. Experientia 6, 103–106 (1950). https://doi.org/10.1007/BF02153375

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