5-[nitro-thiazolyl-(2)]-2-oxo-tetrahydroimidazole was found to possess schistosomicidal and amoebicidal properties. In mice this substance exhibited a curative effect in experimental infections withS. mansoni andS. japonicum. Preliminary clinical trials indicated that the compound is effective and well tolerated in the treatment of vesical bilharziasis.
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Lambert, C.R., Wilhelm, M., Striebel, H. et al. Eine neue gegen Bilharziose und Amoebiase wirksame Verbindung. Experientia 20, 452–453 (1964). https://doi.org/10.1007/BF02152146