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Heterocyclic steroids. Steroidal pyrimidines


Die erste Synthese eines Steroid-Analogen, in welchem Ring A zu einem Pyrimidin umgewandelt wurde, wird beschrieben. Die wichtigste Zwischenstufe 4b wurde durch Abbau von 19-nor-Testosteron gewonnen. Kondensation von 4b mit Thioharnstoff führte zu 17β-Acetoxy-2,4-diazaestr-4-en-1-on-3-thion (5).

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(a) This research was supported by U.S. Public Health Service Grant No. A-5326; (b) Part IV of Heterocyclic Steroids. Part III, seeE. Caspi, P. K. Grover, andD. M. Piatak, Chem. and Ind., in press.

Recipient Public Health Service Research Career Program Award CA-K3-16614 from the National Cancer Institute.

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Caspi, E., Piatak, D.M. Heterocyclic steroids. Steroidal pyrimidines. Experientia 19, 465–466 (1963). https://doi.org/10.1007/BF02150648

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  • Steroid
  • Pyrimidin
  • Thioharnstoff
  • Heterocyclic Steroid