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Morphology and permeability properties of blood capillaries in extraocular muscles of macaque monkeys

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Abstract

Extrinsic eye muscles are very different from other skeletal muscles with regard to the morphology of their fibers and response to drugs. In addition, they are provided with an unusually rich blood supply. Since it had been previously reported that the capillaries of extraocular muscles are, at least in part, of the fenestrated type, a feature unusual for skeletal muscles, we have analyzed the morphology of these vessels in macaque monkeys and tested their permeability properties with horseradish peroxidase (HRP). Our study of the blood capillaries in the superior rectus muscle and levator palpebrae superioris inMacaca mulatta andM. fascicularis has demonstrated that these vessels are morphologically similar to the capillaries of other skeletal muscles. Furthermore, when HRP is introducedintravenam, it is transported out of the vessels by a vesicular transcellular mechanism. When HRP is injected in the interstitial spaces of the muscles, it is returned to the lumen by an identical vesicular transcellular transport. Thus, a bidirectional movement of macromolecules can take place across the walls of these vessels, and such a movement is not different from that previously reported for other skeletal muscles.

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Author information

Correspondence to G. Raviola.

Additional information

Supported by USPHS Grant EY 01349 and Training Grant NS 07152. This study was conducted in part at the New England Regional Primate Research Center, Southborough, Mass., which is supported by NIH grant RR-00168 from the Division of Research Resources

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Mwasi, L.M., Raviola, G. Morphology and permeability properties of blood capillaries in extraocular muscles of macaque monkeys. Graefe's Arch Clin Exp Ophthalmol 223, 9–15 (1985). https://doi.org/10.1007/BF02150567

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Keywords

  • Permeability
  • Skeletal Muscle
  • Macromolecule
  • Blood Supply
  • Horseradish Peroxidase