Intraocular injection of the corticosteroid triamcinolone acetonide reduces the incidence of retinal detachment in rabbit eyes injected with tissue-cultured fibroblasts. When the steroid was injected simultaneously with the cells, a reduction of retinal detachment from 93% (control) to 75% (treated) was achieved on day 28. When the steroid was injected 24 h preceding cell injection, the reduction of retinal detachment was from 85% (control) to 43% (treated). The development of retinal detachment is caused by proliferation of injected fibroblasts. Reduction of this proliferation is probably achieved partially through direct inhibition of mitosis, but more important may be the reduction of the reactive inflammatory process.
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Adams DO, Truner SR (1982) Inflammation. In: Garner A, Klintworth GK (eds) Pathobiology of ocular disease: a dynamic approach, part A. Dekker, New York
Algvere P, Kock E (1976) Experimental fibroplasia in the rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215
Blumenkranz MS, Ophir A, Clafin A, Hajek A (1982) Fluorouracil for the treatment of massive periretinal proliferation. Am J Ophthalmol 94: 458–467
Chandler DB, Rozakis G, deJuan E, Machemer R (1985) The effect of triamcinolone acetonide on a refined experimental model of proliferative vitreoretinopathy. Am J Ophthalmol 99: 686–690
Chandler DB, Quansah FA, Hida T, Machemer R (1986) A refined experimental model for proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 224: 86–91
Claman HN (1983) Glucocorticosteroids I: anti-inflammatory mechanisms. Hosp Pract 18: 123–134
Cupps TR, Fauci AS (1982) Corticosteroid-mediated immunoregulation in man. Immunol Rev 65: 133–155
Dannenberg AM (1979) The antiinflammatory effects of glucocorticosteroids: a brief review of the literature. Inflammation 3: 329–343
Di Rosa M, Calignano A, Carnuccio R, Ialenti A, Sautebin L (1985) Multiple control of inflammation by glucocorticoids. Agents Actions 17: 284–289
Fastenberg DM, Diddie KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565
Fisher CB, Maibach HI (1971) The effect of corticosteroids on human epidermal mitotic activity. Arch Dermatol 103: 39
Hitchens CA, Grierson I, Hiscott PS (1985) The effects of injections of cultured fibroblasts into the rabbit vitreous. Graefe's Arch Clin Exp Ophthalmol 223: 237–249
Jalkh AE, Avila MP, Schepens CL, Azzolini C, Duncan JE, Trempe CL (1984) Surgical treatments of proliferative vitreoretinopathy. Arch Ophthalmol 102: 1135–1139
Koerner F, Gloor B, Merz A, Wagner E (1985) Pre- and postoperative retinal fibrosis. Presented at Paul Cibis Club, Interlaken
Laqua H, Machemer R (1975) Glial cell proliferation in retinal detachment (massive periretinal proliferation) Am J Ophthalmol 80: 602
Machemer R, Laqua H (1975) Pigment epithelium proliferation in retinal detachment (massive periretinal proliferation) Am J Ophthalmol 80: 1
Machemer R (1977) Massive periretinal proliferation. A logical approach to therapy. Trans Am Ophthalmol Soc 75: 556
McCuen B, Landers M, Machemer R (1985) The use of silicone oil following failed vitrectomy for retinal detachment with advanced vitreoretinopathy. Ophthalmology 92: 1029–1034
Parente L, Flower RJ (1985) Glucocorticoid-induced anti-phospholipase proteins. In: Lands WEM (ed) Biochemistry of archidonic acid metabolism. Martinus Nijhoff, Boston, pp 195–201
Ponec M (1984) Effects of glucocorticoids on cultured skin fibroblasts and keratinocytes. Int J Dermatol 23: 11–24
Ruhmann AG, Berliner DL (1965) Effect of steroids on growth of mouse fibroblasts in vitro. Endocrinology 76: 916
SAS Institute Inc. (1982) Basics, SAS users guide. SAS Institute, Cary, NC
Schindler RH, Chandler DB, Thresher R, Machemer R (1982) The clearance of intravitreal triamcinolone acetonide. Am J Ophthalmol 93: 415–417
Sternberg P, Machemer R (1985) Result of conventional vitreous surgery for vitreoretinopathy. Am J Ophthalmol 100: 141–146
Sugita G, Tano Y, Machemer R, Abrams G, Claffin A, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121
Sunalp M, Wiedemann D, Sorgente NJ, Ryan T (1984) Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model. Curr Eye Res 34: 619
Tano Y, Sugita G, Abrams G, Machemer R (1980a) Inhibition of intraocular proliferations with intravitreal corticosteroids. Am J Ophthalmol 89: 131
Tano Y, Chandler D, Machemer R (1980b) Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 90: 810
Wiedemann P, Kirmani M, Santana M, Sorgente N, Ryan SJ (1983) Control of experimental massive periretinal proliferation by daunomycin: dose-response relation. Graefe's Arch Clin Exp Ophthalmol 220: 233–235
Presented at the XVth Meeting of the Club Jules Gonin, Copenhagen, 10–15 August 1986
Supported by National Eye Institute grants EYO2903 and P30-EYO5722; Alcon Laboratories, Forth Worth, Texas; Research To Prevent Blindness, Inc.; The Helena Rubinstein Foundation; and a Dolly Green Scholarship to Dr. Proia from Research To Prevent Blindness, Inc.
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Chandler, D.B., Hida, T., Sheta, S. et al. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefe's Arch Clin Exp Ophthalmol 225, 259–265 (1987). https://doi.org/10.1007/BF02150144
- Public Health
- Animal Model
- Inflammatory Process