Experientia

, Volume 18, Issue 5, pp 224–226 | Cite as

Lesions in folic acid metabolism induced by primidone

  • H. Baker
  • O. Frank
  • S. H. Hutner
  • S. Aaronson
  • H. Ziffer
  • H. Sobotka
Kurze Mitteilungen

Keywords

Folic Acid Thymidine Acid Metabolism Cela Primidone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Les auteurs ont étudié le mécanisme de la toxicité de la primidone (Mysoline) chez certains microorganismes. Ces recherches montrent que le métabolisme de l'acide folique est inhibé par le primidone et cela en trois étapes: (a) la réduction de l'acide folique en acide dihydrofolique, (b) le métabolisme des ptéridines nonconjugées et (c) la phosphorylation de la thymidine.

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Copyright information

© Birkhäuser Verlag 1962

Authors and Affiliations

  • H. Baker
    • 1
    • 2
    • 3
  • O. Frank
    • 1
    • 2
    • 3
  • S. H. Hutner
    • 1
    • 2
    • 3
  • S. Aaronson
    • 1
    • 2
    • 3
  • H. Ziffer
    • 1
    • 2
    • 3
  • H. Sobotka
    • 1
    • 2
    • 3
  1. 1.Division of Hepatic Metabolism and NutritionSeton Hall College of MedicineJersey City
  2. 2.Haskins LaboratoriesNew York
  3. 3.Department of ChemistryMount Sinai HospitalNew YorkUSA

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