The synthesis of a new class of adrenergicβ-receptor blocking agents based upon ao-allyloxy-phenoxy-propanolamine structure is described. The structure activity relationships were studied, and the structural elements responsible for an optimal pharmacological effect are discussed.
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Wilhelm, M., Hedwall, P. & Meier, M. o-Allyloxy-phenoxy-propanolamine, eine neue Gruppe adrenergischer β-Rezeptoren-Blocker. Experientia 23, 651–652 (1967). https://doi.org/10.1007/BF02144181