A refined experimental model for proliferative vitreoretinopathy

  • D. B. Chandler
  • F. A. Quansah
  • T. Hida
  • R. Machemer
Article
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Accepted:

Abstract

Animal models of proliferative vitreoretinopathy (PVR) in which the intact vitreous is injected with large numbers of tissue cultured fibroblasts do not accurately represent the disease as it is found in humans. A refined model of PVR is presented, in which the vitreous is compressed and partially detached using intravitreally injected perfluorpropane, followed by injection of 25,000 homologous fibroblasts. Proliferation occurred on the retinal surface, causing retinal detachments with the same frequency as models using greater numbers of cells.

Keywords

Public Health Animal Model Experimental Model Retinal Detachment Refined Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Algevere P, Kock E (1976) Experimental fibroplasia in rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215Google Scholar
  2. Fastenburg DM, Diddie KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565–572PubMedGoogle Scholar
  3. Gonvers N, Thresher R (1983) Temporary use of silicone oil in the treatment of proliferative vitreoretinopathy: an experimental study with a new animal model. Graefe's Arch Clin Exp Ophthalmol 221: 46–53Google Scholar
  4. Lincoff A, Kreissig I (1981) Intravitreal behavior of perfluorocarbons. Dev Ophthalmol 2: 17PubMedGoogle Scholar
  5. Sugita G, Tano Y, Machemer R, Abrams G, Claflin A, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121–130PubMedGoogle Scholar
  6. Thresher RJ, Ehrenberg M, Machemer R (1984) Gas mediated vitreous compression: an experimental alternative to mechanized vitrectomy. Graefe's Arch Clin Exp Ophthamol 221: 192–198Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • D. B. Chandler
    • 1
  • F. A. Quansah
    • 1
  • T. Hida
    • 1
  • R. Machemer
    • 1
  1. 1.Department of OphthalmologyDuke University Eye Center, DurhamDurhamUSA

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