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Action of histamine on nerve mediated responses of the guinea-pig ileum

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Abstract

The effect of histamine on the responses of the guinea-pig ileum to stimulation of intramural nerves and to some potential nonadrenergic, noncholinergic (NANC) neurotransmitters was analysed. During sustained tonic histamine contraction, electrical stimulation of all intramural nerves elicited a biphasic response (contraction followed by after-relaxation) and application of ATP and bradykinin caused relaxation of the ileum in contrast to their contractile effect on basal tension. Histamine reduced contractile and augmented relaxatory NANC responses, and prevented capsaicin from producing any contractile effect and from significantly influencing the NANC contractions. The present results suggest that, besides its direct effect, histamine activates intramural nerve fibres, mainly the sensory ones, and unmasks NANC relaxation thus modifuing the mechanical activity.

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References

  1. [1]

    I. Bareiche and M. Rocha e Silva,Occurrence of H 2-receptors for histamine in the guinea-pig intestine, Biochem. Pharmacol.24, 1215–1219 (1975).

  2. [2]

    O. Matušák and V. Bauer,Effect of desensitization induced by adenosine 5′-triphosphate, substance P, bradykinin, serotonin, γ-aminobutyric acid and endogenous noncholinergic, nonadrenergic transmiter in the guinea-pig ileum, Eur. J. Pharmacol.126, 199–209 (1986).

  3. [3]

    P. Kitabgi and P. Freychet,Effect of neurotensin on isolated intestinal smooth muscles, Eur J. Pharmacol.50, 349–357 (1978).

  4. [4]

    L. Barthó, F. Lembeck and P. Holzer,Calcitonin gene-related peptide is a potent relaxant of intestinal muscle, Eur. J. Pharmacol, in press.

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Author information

Correspondence to V. Bauer.

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Matušák, O., Bauer, V. Action of histamine on nerve mediated responses of the guinea-pig ileum. Agents and Actions 23, 244–246 (1988). https://doi.org/10.1007/BF02142553

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Keywords

  • Direct Effect
  • Histamine
  • Electrical Stimulation
  • Nerve Fibre
  • Capsaicin