Histamine release from human basophil leukocytes was triggered byStaph. aureus or by complement activation caused by endotoxins isolated fromE. coli or Salmonella bacteria. Influenza A virus was found to enhance the mediator release and the effects was caused by synergism, since the virus itself did not release histamine. The potentiating effect of the virus was abolished by a potent neuraminidase inhibitor. Furthermore, a purified neuraminidase preparation obtained fromVibrio cholerae caused a similar potentiating effect, which was also abolished by the neuraminidase inhibitor. These findings indicate that the neuraminidase on the surface of influenza A virus is responsible for the potentiating effect of the virus on basophil histamine release.
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Clementsen, P., Jensen, C.B., Jarløv, J.O. et al. Virus enhances histamine release from human basophils. Agents and Actions 23, 165–167 (1988). https://doi.org/10.1007/BF02142529
- Complement Activation
- Histamine Release
- Mediator Release