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Agents and Actions

, Volume 23, Issue 3–4, pp 157–160 | Cite as

Anti-allergic constituents in the culture medium ofGanoderma lucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release

  • K. Tasaka
  • M. Mio
  • K. Izushi
  • M. Akagi
  • T. Makino
Histamine Release

Abstract

For centuries,Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constitutents was cyclooctasulfur. The latter effectively inhibited hsitamine release from rat peritoneal mast cells and impeded45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit45Ca uptake, and that this may be the main cause of histamine release inhibition.

Keywords

Mast Cell Bronchitis Membrane Fraction Chronic Bronchitis Histamine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • K. Tasaka
    • 1
  • M. Mio
    • 1
  • K. Izushi
    • 1
  • M. Akagi
    • 1
  • T. Makino
    • 2
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan
  2. 2.Research DivisionSunstar Inc.Takatsuki, OsakaJapan

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