Anti-allergic constituents in the culture medium ofGanoderma lucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release
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For centuries,Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constitutents was cyclooctasulfur. The latter effectively inhibited hsitamine release from rat peritoneal mast cells and impeded45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit45Ca uptake, and that this may be the main cause of histamine release inhibition.
KeywordsMast Cell Bronchitis Membrane Fraction Chronic Bronchitis Histamine Release
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