Journal of Molecular Evolution

, Volume 27, Issue 2, pp 102–108 | Cite as

Structure of the human hemopexin gene and evidence for intron-mediated evolution

  • F. Altruda
  • V. Poli
  • G. Restagno
  • L. Silengo


The human hemopexin gene was isolated and its structure determined. The gene spans approximately 12 kb and is interrupted by nine introns. When the intron/exon pattern was examined with respect to the polypeptide segments they encode, a direct correspondence between exons and the 10 repeating units in the protein was observed. The introns are not randomly placed; they fall in the middle of the region of amino acid sequence homology in strikingly similar locations in 6 of the 10 units and in a symmetrical position in the two halves of the coding sequence. These features strongly support the hypothesis that the gene evolved through intron-mediated duplications of a primordial sequence to a five-exon cluster. A more recent gene duplication led to the present-day gene organization.

Key words

Hemopexin Evolution Gene structure Recombination Sequence homology 


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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • F. Altruda
    • 1
  • V. Poli
    • 1
  • G. Restagno
    • 1
  • L. Silengo
    • 1
  1. 1.Cattedra di Biologia GeneraleTorinoItaly

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