Molecular evolution and phylogeny of the human AIDS viruses LAV, HTLV-III, and ARV
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A phylogenetic tree for the human lymphadenopathy-associated virus (LAV), the human T-cell lymphotrophic virus type III (HTLV-III), and the acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) has been constructed from comparisons of the amino acid sequences of their gag proteins. A method is proposed for estimating the divergence times among these AIDS viruses and the rates of nucleotide substitution for their RNA genomes. The analysis indicates that the LAV and HTLV-III strains diverged from one another after 1977 and that their common ancestor diverged from the ARV virus no more than 10 years earlier. Hence, the evolutionary diversity among strains of the AIDS viruses apparently has been generated within the last 20 years. It is estimated that the genome of the AIDS virus has a nucleotide substitution rate on the order of 10−3 per site per year, with the rate in the second half of the genome being double that in the first half.
Key wordsHuman AIDS viruses Molecular evolution Phylogeny
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- Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871PubMedGoogle Scholar
- Gojobori T, Yokoyama S (1985) Rates of evolution of the retroviral oncogene of Moloney murine sarcoma virus and of its cellular homologues. Proc Natl Acad Sci USA 82:4198–4201Google Scholar
- Gojobori T, Yokoyama S, Maruyama T (1985) DNA polymorphism of acquired immune deficiency syndrome virus. Genetics 110:s91Google Scholar
- Jukes TH, Cantor CR (1969) Evolution of protein molecules. In: Munro HN (ed) Mammalian Protein Metabolism II. Acdemic Press, New York, p 21Google Scholar
- Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge, EnglandGoogle Scholar
- Nei M (1983) Genetic polymorphism and the role of mutation in evolution. In: Nei M, Koehn RK (eds) Evolution of genes and proteins. Sinauer Associates, Sunderland, Massachusetts, p 165Google Scholar
- Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski JA, Whitehorn EA, Baumeister K, Ivanoff L, Petteway SR, Pearson ML, Lautenberger JA, Papas TS, Ghrayeb J, Chang NT, Gallo RC, Wong-Staal F (1985b) Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313:277–284CrossRefPubMedGoogle Scholar
- Sanchez-Pescador R, Power MD, Barr PJ, Steimer KS, Stempien MM, Brown-Shimer SL, Gee WW, Renard A, Randolph A, Levy JA, Dina D, Luciw PA (1985) Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science 484–492Google Scholar