International Urology and Nephrology

, Volume 2, Issue 2, pp 187–197 | Cite as

Testicular histology in Klinefelter's syndrome

  • C. Schirren
  • J. O. Toyosi
  • I. Wurst
Article

Abstract

In 36 patients the diagnosis of Klinefelter's syndrome could not be made from the somatic status. A germinative sex examination must usually be carried out. Some set rules which are not applicable to all cases are outlined. Bearing this in mind, 3 groups are set up (excessive Leydig cell hyperplasia without tubuli, excessive Leydig cell hyperplasia with tubuli, incomplete or complete spermiogenesis) which will enable a better study. The relevant findings are tabulated and discussed. It shows that in Klinefelter's syndrome a great variability of testicular histology is to be expected. Special attention is devoted to 2 cases of histologically confirmed testicular spermatogenesis and aspermia in the ejaculate. It is suggested that a chromosomal disorder goes hand in hand with testicular histological findings, whereby all variations are possible.

Keywords

Public Health Histological Finding Great Variability Leydig Cell Cell Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Balze, F. de la, Arillaga, F. C., Irazu, J., Mancini, R. E.: Klinefelter's syndrome: A study of 5 cases.J. clin. Endocr. 12, 227 (1952).Google Scholar
  2. 2.
    Barr, M. L., Bertram, E. G.: A morphological distinction between neurones of the male and female and the nucleolar satellite during accelerated nucleoprotein synthesis.Nature 163, 676 (1949).Google Scholar
  3. 3.
    Bergmann, S., Reitalu, J.: Chromosomenbefunde beim Klinefelter Syndrom.Arch. klin. exp. Derm. 213, 769 (1961).Google Scholar
  4. 4.
    Bradbury, J. T., Bunge, R. G., Boccabella, R. A.: Chromatin test in Klinefelter's syndrome.J. clin. Endocr. 689 (1956).Google Scholar
  5. 5.
    Bunge, R. G., Bradbury, J. T.: Newer concepts of the Klinefelter's syndrome.J. Urol. 76, 758 (1956).PubMedGoogle Scholar
  6. 6.
    Bunge, R. G., Bradbury, J. T.: Genetic sex: Chromatin test versus gonadal histology.J. clin. Endocr. 16, 1117 (1956).PubMedGoogle Scholar
  7. 7.
    Carr, D. H., Barr, M. L. Plunkett, E. R., Grumbach, M. M.: An XXXY sex chromosome complex in Klinefelter's subjects with duplicated sex chromatin.J. clin. Endocr. 21, 491 (1961).PubMedGoogle Scholar
  8. 8.
    Cornwell, J. G., Herrmann, W.: Intersexuality in mentally deficient patients.Acta endocr. 27, 369 (1958).PubMedGoogle Scholar
  9. 9.
    Crooke, A. C., Hayward, M. D.: Mosaicism in Klinefelter's syndrome.Lancet 1960/I, 1198.Google Scholar
  10. 10.
    Davidson, W. M., Smith, D. R.: A morphological sex difference in the polymorphonuclear neutrophile leukocytes.Brit. med. J. 2, 6 (1954).Google Scholar
  11. 11.
    Davis, T. E., Canfield, C. J., Herman, R. H., Goler, D.: Thyroid function in patients with aspermiogenesis and testicular tubular sclerosis.New Engl. J. Med. 268, 178 (1963).PubMedGoogle Scholar
  12. 12.
    Ferguson-Smith, M. A., Johnston, A. W., Handmaker, S. D.: Primary amentia and microorchidism associated with an XXXY sex-chromosome constitution.Lancet 1960/II, 184.Google Scholar
  13. 13.
    Ferguson-Smith, M. A., Lennox, B., Mack, W. S., Stewart J. S. S.: Klinefelter's syndrome, frequency and testicular morphology in relation to nuclear sex.Lancet 1957/II, 167.Google Scholar
  14. 14.
    Harrer, G.: Kasistischer Beitrag zur Pathogenese des Klinefelter Syndroms.Wien. klin. Wschr. 70, 280 (1958).PubMedGoogle Scholar
  15. 15.
    Heinke, E. und Doepfmer, R.: Das Klinefelter Syndrom. In Jadassohns Handbuch der Haut- und Geschlechtskrankheiten Erg. Werk Band VI/3, Springer Verl, Berlin-Göttingen-Heidelberg 1960.Google Scholar
  16. 16.
    Heller, C. G., Nelson, W. O.: Hyalinization of the seminiferous tubules associated with normal or failing Leydig cell function. Microscopic picture in the testis and associated changes in the breast.J. clin. Endocr. 5, 13 (1945).Google Scholar
  17. 17.
    Holub, D. A., Grumbach, M. M., Jailer, J. W.: Seminiferous tubule dysgenesis (Klinefelter syndrome in identical twins).J. clin. Endocr. 18, 1359 (1958).PubMedGoogle Scholar
  18. 18.
    Hornstein, O.: Zur Klinik und Histopathologie des männlichen Hypogonadismus, Kastratismus und sog. Klinefelter-Syndrom als Krankheitsformen mit bekannter Aetiologie.Arch. klin. exp. Derm. 217, 149 (1963).PubMedGoogle Scholar
  19. 19.
    Jacobs, P. A., Strong, J. A.: A case of human intersexuality having a possible XXY-sexdeterming mechanism.Nature 183, 302 (1959).PubMedGoogle Scholar
  20. 20.
    Jirasek, J., Raboch, J.: Über das Sexchromatin bei Männern mit somatosexuellen Entwicklungsstörungen.Endokrinologie 35, 1 (1957).PubMedGoogle Scholar
  21. 21.
    Kiessling, W., Hienz, H. A.: Die Bedeutung der zellkernmorphologischen Geschlechtserkennung für die Dermatologie unter besonderen Berücksichtigung des sog. Klinefelter-Syndroms.Arch. klin. exp. Derm. 205, 93 (1957).PubMedGoogle Scholar
  22. 22.
    Klinefelter, H. F., Reifenstein, E. C., Albright, F.: Syndrome characterized by gynecomastia, aspermatogenesis without A-Leydigism increased excretion of follicle-stimulating hormone.J. clin. Endocr. 2, 615 (1942).Google Scholar
  23. 23.
    Kosenow, W.: Neue Ergebnisse der Chromosomenforschung und ihre Bedeutung für die klinische pathologie.Arch. Kinderheilk. 162, 219 (1960).PubMedGoogle Scholar
  24. 24.
    Lenz, W.: Zur Aetiologie des Klinefelter-Syndroms.Arch. klin. exp. Derm. 213, 771 (1961).Google Scholar
  25. 25.
    Lenz, W., Nowakowski, H., Prader, A., Schirren, C.: Die Aetiologie des Klinefelter-Syndroms.Schweiz. med. Wschr. 89, 727 (1959).PubMedGoogle Scholar
  26. 26.
    Nielsen, J., Sörensen, A., Theilgaard, A., Fröland, A., Johnsen, S. G.: A psychiatric-psychological study of 50 severely hypogonadal patients, including 34 with Klinefelter's syndrome, 47, xxy. Acta Jutlandica XLI: 3, Köbenhavn: Munksgaard 1969.Google Scholar
  27. 27.
    Niermann, H.: Spermiogenese beim Klinefelter-Syndrom.Z. mensch. Vererb. u. Konstit. Lehre 36, 236 (1961).Google Scholar
  28. 28.
    Niermann, H.: Chromosomale Störungen und ihre Bedeutung für die Andrologie und Dermatologie. In Jadassohns Handbuch der Haut- und Geschlechtskrankheiten Erg. Werk. Band VII, p. 130, Springer Verl. Heidelberg-New York: 1966.Google Scholar
  29. 29.
    Nowakowski, H., Lenz, W., Bergmann, S., Reitalu, J.: Chromosomenbefunde beim Klinefelter-Syndrom.Acta endocr. 34, 483 (1960).Google Scholar
  30. 30.
    Ohno, S., Kaplan, W. D., Kinosita, R.: Formation of the sex chromatin by a single X-chromosome in liver cells of Rattus norvegicus.Exp. Cell. Res. 18, 415 (1959).PubMedGoogle Scholar
  31. 31.
    Ohno, S., Makino, S., Kaplan, W. D., Kinosita, R.: Female germ cells of man.Exp. Cell. Res. 24, 106 (1961).PubMedGoogle Scholar
  32. 32.
    Overzier, C.: Die Intersexualität. Thieme, Stuttgart 1961.Google Scholar
  33. 33.
    Raboch, J., Bleha, O.: Über ein echtes Klinefelter Syndrom mit kompletter Spermiogenese.Endokrinologie 39, 203 (1960).PubMedGoogle Scholar
  34. 34.
    Schirren, C.: Zur Problematik des Klinefelter Syndroms.Arch. klin. exp. Derm. 211, 134 (1960).PubMedGoogle Scholar
  35. 35.
    Schirren, C.: Neue Ergebnisse der Andrologie. Springer, Berlin-Heidelberg-New York 1965.Google Scholar
  36. 36.
    Schirren, C.: Klinik der Andrologie.Internist 8, 2 (1967).PubMedGoogle Scholar
  37. 37.
    Schirren, C., Jänner, M.: Gemeinsames Auftreten von hyperlipidämischer Xanthomatose und Klinefelter Syndrom.Hautarzt 16, 80 (1965).PubMedGoogle Scholar
  38. 38.
    Schwarzacher, H. G.: Die Beziehungen zwischen Geschlechtschromatin und Geschlechtschromosomen.Wien. klin. Wschr. 74, 481 (1962).PubMedGoogle Scholar
  39. 39.
    Segal, S. Y., Nelson, W. O.: Developmental aspects of human hermaphroditism. The significance of sex chromatin pattern.J. clin. Endocr. 17, 676 (1957).PubMedGoogle Scholar
  40. 40.
    Siebenmann, R.: Hodenmorphologie und chromosomales Geschlecht.Schweiz. med. Wschr. 87, 302 (1957).Google Scholar
  41. 41.
    Tonutti, E., Weller, O., Schuchardt, E., Heinke, E.: Das Klinefelter-Syndrom. In Die männliche Keimdrüse, Thieme, Stuttgart 1960.Google Scholar
  42. 42.
    Warburg, E.: Fertilität beim Klinefelter Syndrom.Ugeskr. Laeg. 124, 1265 (1962).PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó 1970

Authors and Affiliations

  • C. Schirren
    • 1
  • J. O. Toyosi
    • 1
  • I. Wurst
    • 1
  1. 1.Department of AndrologyUniversity Clinic of DermatologyHamburg

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