European Journal of Pediatrics

, Volume 152, Supplement 2, pp S38–S42 | Cite as

The behavior of epididymis, processus vaginalis and testicular descent in cryptorchid boys treated with buserelin

  • Domingos TG Bica
  • Faruk Hadziselimovic
Cryptorchidism and Male Pseudo-Hermaphroditism


This randomized double-blind placebo-controlled study was initiated to analyze the behavior of epididymis, processus vaginalis and testicular descent in cryptorchid boys treated with a low dose (20 μg) of a luteinizing hormone-releasing hormone analogue (Buserelin), administered daily, as a nasal spray, for a short period (28 days). Fifty-nine true cryptorchid boys were randomly assigned to 3 groups: buserelin, treatment [22], surgical treatment [18] or placebo control group [19]. The 3 groups of patients were similar before treatment in regard to testicular position, chronological and bone age, height and weight, luteinizing hormone, follicle-stimulating hormone, testosterone, penile size and the volume of the contralateral descended testis. None of the patients had retractile testes. Buserelin significantly induced testicular descent compared to the boys treated with a placebo (P<0.01). A normal epididymis was found more often in boys with successful descent (P<0.003). A closed processus vaginalis was also more frequently observed in the group treated with buserelin than in surgically treated one (P<0.05). In conclusion, buserelin was capable of inducing testicular descent besides provoking further development of the epididymis and closing the processus vaginalis.

Key words

Buserelin acetate Cryptorchism Epididymis Processus vaginalis Double-blind method 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Domingos TG Bica
    • 1
  • Faruk Hadziselimovic
    • 2
  1. 1.Department of Pediatric SurgeryFederal University Children's Hospital in Rio de JaneiroRio de JaneiroBrazil
  2. 2.Basler Children's HospitalUniversity ClinicsBaselSwitzerland

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