Experientia

, Volume 48, Issue 8, pp 741–745

Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice

  • J. M. Kyd
  • R. N. Murdoch
Research Articles

Abstract

Intraluminal injections (15 μl) of either concanavalin A (125 μg) or ionophore A 23187 (0.01 μmol) induced a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15 μmol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.

Key words

Decidualization pseudopregnancy uterine biochemistry polyphosphatidylinositol pathway concanavalin A calcium ionophore phorbol ester 

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References

  1. 1.
    Finn, C. A., Biol. Rev.61 (1986), 313.CrossRefPubMedGoogle Scholar
  2. 2.
    Lejeune, B., Van Hoeck, J., and Leroy, F., J. Reprod. Fer.61 (1981) 235.CrossRefGoogle Scholar
  3. 3.
    Kennedy, T. G., in: Eicosanoids and Reproduction, p. 73. Ed. K. Hilier, MTP Press, Lancaster 1987.Google Scholar
  4. 4.
    Feyles, V., and Kennedy, T. G., Biol. Reprod.37 (1987) 96.PubMedGoogle Scholar
  5. 5.
    Nishizuka, Y., Science233 (1986) 305.PubMedGoogle Scholar
  6. 6.
    Buxton, L. E., and Murdoch, R. N., Aust. J. biol. Sci.35 (1982) 63.PubMedGoogle Scholar
  7. 7.
    Wassef, N. M., Richardson, C. R., and Alving, C. R., Biochem. biophys. Res. Commun.130 (1985) 76.CrossRefPubMedGoogle Scholar
  8. 8.
    Isakov, N., Scholz, W., and Altman, A., Immunology Today7 (1986) 271.CrossRefGoogle Scholar
  9. 9.
    Gukovskaya, A. S., Pulido, H. A., Petrunyaka, V. V., Zinchenko, Z. P., and Bezuglov, V. V., Cell Calcium11 (1990) 539.CrossRefPubMedGoogle Scholar
  10. 10.
    Cheung, W. Y., Calmodulin Sci. Am.246 (1982) 48.Google Scholar
  11. 11.
    Berridge, M. J., Biochim. biophys. Acta907 (1987) 33.PubMedGoogle Scholar
  12. 12.
    Irvine, R. F., Biochem. J.204 (1982) 3.PubMedGoogle Scholar
  13. 13.
    Bonney, R. G., and Franks, S., Clin. Endocr.27 (1987) 307.PubMedGoogle Scholar
  14. 14.
    Hollingsworth, E. B., Ukena, D., and Daly, J. W., FEBS Lett.196 (1986), 131.CrossRefPubMedGoogle Scholar
  15. 15.
    Yoshimasa, T., Sibley, D. R., Bouvier, M., Lefkowitz, R. J., and Caron, M. C., Nature327 (1987) 67.CrossRefPubMedGoogle Scholar
  16. 16.
    Aasheim, L. H., Klein, L. P., and Franks, D. J., Cell Sign.1 (1989) 617.CrossRefGoogle Scholar
  17. 17.
    Visconti, P. E., and Tezon, J. G., Biol. Reprod.40 (1989) 223.PubMedGoogle Scholar
  18. 18.
    Sananes, N., Baulieu, E., and Le Goascogne, C., J. Endocr.89 (1981) 25.PubMedGoogle Scholar
  19. 19.
    Keys, J. L., and Kennedy, T. G., Am. J. Anat.188 (1990) 148.CrossRefPubMedGoogle Scholar
  20. 20.
    Martel, D., Monier, M. N., Roche, D., and Psychoyos, A., J. Reprod. Fer.85 (1989) 527.CrossRefGoogle Scholar
  21. 21.
    Fortier, M. A., Boulet, A. P., and Lambert, R. D., J. Reprod. Fer.85 (1989) 443.CrossRefGoogle Scholar
  22. 22.
    Fortier, M. A., Boulet, A. P., Dugre, F. J., and Lambert, R. D., Biol. Reprod.42 (1990) 106.PubMedGoogle Scholar
  23. 23.
    Berridge, M. J., Brown, K. D., Irvine, R. F., and Heslop, J. P., J. Cell Sci. Suppl.3 (1985) 188.Google Scholar
  24. 24.
    Taylor, M. V., Metcalf, J. C., Hesketh, T. R., Smith, G. A., and Moore, J. P., Nature312 (1984) 462.CrossRefPubMedGoogle Scholar
  25. 25.
    Wassef, N. M., and Alving, C. R., Biochem. biophys. Res. Commun.138 (1986) 1090.CrossRefPubMedGoogle Scholar
  26. 26.
    Conquer, J., and Mahadavappa, V. G., Biochem. biophys. Res. Commun.167 (1990) 168.CrossRefPubMedGoogle Scholar
  27. 27.
    Murdoch, R. N., Kay, D. J., and Cross, M., J. Reprod. Fert.54 (1978) 293.Google Scholar
  28. 28.
    Kikkawa, U., and Nishizuka, Y., A. Rev. Cell Biol.2 (1986) 149.CrossRefGoogle Scholar
  29. 29.
    Finn, C. A., and Martin, L., J. Endocr.45 (1969) 57.PubMedGoogle Scholar
  30. 30.
    Katakami, Y., Kaibuchi, M., Sawamura, M., Takai, Y., and Nishizuka, Y., Biochem. biophys. Res. Commun.121 (1984) 573.CrossRefPubMedGoogle Scholar
  31. 31.
    Yamanshi, J., Takai, Y., Kaibuchi, K., Sano, K., Castagna, M., and Nishizuka, Y., Biochem. biophys. Res. Commun.112 (1983) 778.CrossRefPubMedGoogle Scholar
  32. 32.
    Wang, J., and Leung, P. C. K., Biol. Reprod.40 (1989) 1000.PubMedGoogle Scholar
  33. 33.
    Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y., J. biol. Chem.257 (1982) 7847.PubMedGoogle Scholar
  34. 34.
    Berridge, M. J., biol. Chem.265 (1990) 9583.Google Scholar
  35. 35.
    Burgess, G. M., McKinney, J. S., Irvine, R. F., and Putney, J. W. Jr, Biochem. J.232 (1985) 237.PubMedGoogle Scholar
  36. 36.
    Bazzi, M. D., and Nelsestuen, G. L., Biochemistry28 (1989) 9317.CrossRefPubMedGoogle Scholar
  37. 37.
    Leung, P. C. K., and Wang, J., Biol. Reprod.40 (1989) 703.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1992

Authors and Affiliations

  • J. M. Kyd
    • 1
  • R. N. Murdoch
    • 1
  1. 1.Department of Biological SciencesThe University of NewcastleNewcastleAustralia

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