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Medical Microbiology and Immunology

, Volume 165, Issue 2, pp 111–117 | Cite as

Protection induced by inactivated influenza virus vaccines with polymethylmethacrylate adjuvants

  • Jörg Kreuter
  • Ekke Liehl
Article

Abstract

Nanocapsules from a copolymer of polymethylmethacrylate and polyacrylamide were tested for adjuvant activity in mouse protection experiments with inactivated influenza virus as antigen. Viruses were either adsorbed on the capsules after polymerization or added to the monomers and incorporated by copolymerization after X-ray initiation. Both preparations showed enhanced immunity as compared to fluid vaccine, if the adjuvant content was 1%. The adjuvant effect was comparable to that caused by the mineral adjuvant Al(OH)3. After dilution of the polymer the adjuvant effect was lost. Such synthetic polymers at suitable concentrations could serve as alternatives to mineral adjuvants.

Keywords

Polymer Influenza Polyacrylamide Polymethylmethacrylate Influenza Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Jörg Kreuter
    • 1
    • 2
  • Ekke Liehl
    • 1
    • 2
  1. 1.Department of Pharmaceutical TechnologySwiss Federal Institute of TechnologyZürichSwitzerland
  2. 2.Sandoz Forschungsinstitut Gesellschaft M.B.H.ViennaAustria

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