Medical Microbiology and Immunology

, Volume 168, Issue 2, pp 139–148 | Cite as

The effect of lithium chloride on the replication ofHerpes simplex virus

  • G. R. B. Skinner
  • C. Hartley
  • A. Buchan
  • L. Harper
  • P. Gallimore
Original Investigations


Lithium chloride inhibited the replication of type 1 and type 2Herpes simplex virus at concentrations which permitted host cell replication. Virus polypeptide and antigen synthesis were unaffected while viral DNA synthesis was inhibited. The replication of two other DNA viruses, pseudorabies and vaccinia virus, was inhibited but there was no inhibition of two RNA viruses, namely, EMC and influenza virus.


Chloride Lithium Influenza Polypeptide Host Cell 
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • G. R. B. Skinner
    • 1
  • C. Hartley
    • 1
  • A. Buchan
    • 1
  • L. Harper
    • 1
  • P. Gallimore
    • 2
  1. 1.Department of Medical Microbiology, Medical SchoolUniversity of BirminghamEngland
  2. 2.Department of Cancer Studies, Medical SchoolUniversity of BirminghamEngland

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