Klinische Wochenschrift

, Volume 68, Issue 5, pp 286–289 | Cite as

Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and β-interferon time course of intracranial pressure

  • A. Schmidt
  • D. Bunjes
  • J. Friedrich
  • W. Koenig
  • T. Eggeling
  • V. Hombach
Case Reports


A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir andβ-interferon. The increase in intracranial pressure during the second week was well controlled by ICP monitoring. Life-threatening pressure peaks were avoided through the use of thiopental, osmodiuretics, TRIS, and lidocaine.

Key words

Herpes-Simplex encephalitis Intracranial pressure monitoring 



Intracranial pressure


Herpes simplex encephalitis


Cerebral perfusion pressure


Heart rate


mean arterial pressure


Cerebral computer tomography


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • A. Schmidt
    • 1
  • D. Bunjes
    • 2
  • J. Friedrich
    • 3
  • W. Koenig
    • 1
  • T. Eggeling
    • 1
  • V. Hombach
    • 1
  1. 1.Innere Medizin IVUniversitätsklinik UlmDeutschland
  2. 2.Innere Medizin IIIUniversitätsklinik UlmDeutschland
  3. 3.Department für RadiologieUniversitätsklinik UlmDeutschland

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