Use of norfloxacin for prevention of symptomatic urinary tract infection in chronically catheterized patients

  • O. T. Rutschmann
  • A. Zwahlen


Thirty-four elderly inpatients with long-term urethral catheters were randomly assigned to receive either norfloxacin (200 mg/day) or placebo in a double-blind study with cross-over after three months. Twenty-three patients completed the entire study. Norfloxacin treatment was associated with a persistent decrease in gram-negative isolates (p<0.005) and the acquisition of gram-positive norfloxacin-resistant flora. It also resulted in a highly statistically significant reduction of symptomatic urinary tract infections (1 vs. 12, p<0.02), a decrease in catheter-associated local complications, obstructions and leakage (p<0.05) and an improvement in the patients' general condition (p<0.001). In conclusion, within the conditions of the present study, long-term suppression of gramnegative bacteriuria by norfloxacin reduced the incidence of catheter-related urinary tract infection and associated morbidity.


Placebo Catheter Internal Medicine Urinary Tract Tract Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1995

Authors and Affiliations

  • O. T. Rutschmann
    • 1
  • A. Zwahlen
    • 2
  1. 1.Department of Medicine, Division of Infectious DiseasesUniversity HospitalGeneva 14Switzerland
  2. 2.Department of MedicineHôpital de Zone de Saint-Loup/OrbePompaplesSwitzerland

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