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Pharmacy World and Science

, Volume 15, Issue 3, pp 139–144 | Cite as

Effect of pH on absorption of sufentanil citrate in a portable pump reservoir during storage and administration under simulated epidural conditions

  • P. J. Roos
  • J. H. Glerum
  • J. W. Meilink
  • L. Zwang
Practice/Case Reports

Abstract

Sufentanil (5μg/ml as citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32°C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of sufentanil (5μg/ml as citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of sufentanil after 48 h in both experiments. The effect of the pH on the absorption of sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32°C there was 5.1% loss of sufentanil at pH 4 and 80.6% loss at pH 6. The citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.

Keywords

Absorption Buffer capacity Epidural administration Polyvinyl chloride Stability Storage Sufentanil 

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Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1993

Authors and Affiliations

  • P. J. Roos
    • 1
  • J. H. Glerum
    • 2
    • 3
  • J. W. Meilink
    • 4
  • L. Zwang
    • 5
  1. 1.Department of PharmacyAcademic Medical CentreAZ Amsterdamthe Netherlands
  2. 2.Department of PharmacyUniversity Hospital UtrechtCX Utrechtthe Netherlands
  3. 3.Department of Pharmaceutics, Faculty of PharmacyUniversity of UtrechtCA Utrechtthe Netherlands
  4. 4.Department of PharmacyUniversity Hospital Rotterdam-DijkzigtGD Rotterdamthe Netherlands
  5. 5.Department of Clinical ChemistryUniversity Hospital Rotterdam-Dijkzigtthe Netherlands

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