Advertisement

Pharmacy World and Science

, Volume 15, Issue 3, pp 128–131 | Cite as

The use of hypoglycaemic and cardiovascular drugs in 582 patients with diabetes mellitus

Description and quality assessment
  • G. Van den Brink
  • R. R. H. Schwartzenberg
  • L. L. H. Hoeve
  • A. J. Porsius
Articles

Abstract

The medication of 582 patients taking insulin or oral hypoglycaemic agents has been analysed. A characterization is given of the patients and their. antidiabetic medication. Subsequently, a description of the use of cardiovascular drugs, in comparison with an age-matched control group, is presented. The diabetic population investigated has an average age of 67 years. Most cardiovascular agents, with the exception of thiazide diuretics, are used to a larger extent in the diabetic group in comparison with the control group. Non-selectiveβ-blockers, possibly hazardous in patients with diabetes mellitus, appear to be prescribed without restriction in the diabetic patients investigated. The results of this study suggest that the choice of drugs for the treatment of cardiovascular co-morbidity in patients with diabetes mellitus can be improved.

Keywords

Adrenergic beta receptor blockaders Cardiovascular agents Diabetes mellitus Drug utilization Quality of health care 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wolffenbuttel BHR, Sels J-PJE, Verhoeven S, Nieuwenhuijzen-Kruseman AC. Diabetesregulatie en late complicaties bij poliklinisch behandelde patiënten met diabetes mellitus type II [Diabetic control and late complications in out-patients with NIDDM]. Ned Tijdschr Geneeskd 1991;135:2387–91.PubMedGoogle Scholar
  2. 2.
    Sprafka JM, Bender AP, Jagger HG. Prevalence of hypertension and associated risk factors among diabetic individuals. The Three-City Study. Diabetes Care 1988;11:17–22.PubMedGoogle Scholar
  3. 3.
    Teuscher A, Egger M, Herman JB. Diabetes and hypertension — blood pressure in clinical diabetic patients and a control population. Arch Intern Med 1989;149:1942–5.PubMedGoogle Scholar
  4. 4.
    Andersson DKG, Svärdsudd K, Tibblin G. Prevalence and incidence of diabetes in a Swedish community 1972–1987. Diabet Med 1991;8:428–34.PubMedGoogle Scholar
  5. 5.
    Post D, Gubbels JW. Diabetes mellitus is meer dan suikerziekte [Diabetes mellitus is more than Just hyperglycaemia]. Pharm Weekbl 1992;127(11):282–7.Google Scholar
  6. 6.
    Dankmeijer HF. Diabetes mellitus. In: Grobbee DE, Hofman A, eds. Epidemiologie van ziekten in Nederland [Epidemiology of diseases in the Netherlands]. Utrecht: Wetenschappelijke uitgeverij Bunge, 1989:320–9.Google Scholar
  7. 7.
    Feldman HI, Strom BL. Utilisation of drugs for diabetes mellitus. Drug Safety 1991;6:220–9.PubMedGoogle Scholar
  8. 8.
    Rendell M, Lassek WD, Ross DA, Smith C, Kernek S, Williams J, et al. A pharmaceutical profile of diabetic patients. J Chron Dis 1983;36:193–202.PubMedGoogle Scholar
  9. 9.
    Isacson D, Stalhammer J. Prescription drug use among diabetics: a population study. J Chron Dis 1987;40:651–60.PubMedGoogle Scholar
  10. 10.
    Stein PP, Black HR. Drug treatment of hypertension in patients with diabetes mellitus. Diabetes Care 1991;14:425–48.PubMedGoogle Scholar
  11. 11.
    Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 1989;321:868–73.PubMedGoogle Scholar
  12. 12.
    Joseph JC, Schuna AA. Management of hypertension in the diabetic patient. Clin Pharm 1990;9:864–73.PubMedGoogle Scholar
  13. 13.
    O'Byrne S, Feely J. Effects of drugs on glucose tolerance in non-insulin-dependent diabetics (part I). Drugs 1990;40:6–18.PubMedGoogle Scholar
  14. 14.
    Lithell HOL. Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism. Diabetes Care 1991;14:203–9.PubMedGoogle Scholar
  15. 15.
    Sawicki PT, Berger M. Metabolic effects of antihypertensive treatment with betablockers. J Intern Med 1991;229 Suppl 2:97–9.PubMedGoogle Scholar
  16. 16.
    Bengtsson C, Blohmé G, Lapidus L, Lindquist O, Lundgren H, Myström E, et al. Do antihypertensive drugs precipitate diabetes? BMJ 1984;289:1495–7.PubMedGoogle Scholar
  17. 17.
    Van den Brink G, Bollen CW, Van de Wall OEM, Hoeve LJJ, Porsius AJ. A drug use review study in patients with obstructive lung disease — assessment of the quality of drug therapy. Pharm Weekbl [Sci] 1992;14(5):311–5.Google Scholar

Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1993

Authors and Affiliations

  • G. Van den Brink
    • 1
  • R. R. H. Schwartzenberg
    • 1
  • L. L. H. Hoeve
    • 2
  • A. J. Porsius
    • 1
  1. 1.Department of Pharmacotherapy, Faculty of PharmacyUniversity of UtrechtTB UtrechtThe Netherlands
  2. 2.Health Fund Pharmacy “Ziekenzorg”GE UtrechtThe Netherlands

Personalised recommendations

Cite article

Buy options