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Pharmacy World and Science

, Volume 15, Issue 3, pp 116–122 | Cite as

Calcium phosphates in pharmaceutical tableting

2. Comparison of tableting properties
  • P. C. Schmidt
  • R. Herzog
Articles

Abstracts

Ten calcium phosphates suitable for direct compression (dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrous and hydroxylapatite) were investigated with respect to their compressional behaviour. Except for Di-Cafos A all products gave tablets with sufficient to good mechanical strength. Nevertheless, there were differences between the products. All tablets prepared from the different products showed a high friability. This seems to be a problem of the calcium phosphates in general. On the other hand, the influence of magnesium stearate on the mechanical strength of the tablets was negligible for all products investigated. Moreover, a considerable effect of the particle size on the tensile strength of the tablets was found. The ejection forces and residual pressures were high in general, but critical only in the case of hydroxylapatites. Heckel plots were used to differentiate between plastic deformation and brittle fracture of the particles. In the case of calcium phosphates the slope of the Heckel plots indicated the hardness of the particles rather than their deformation behaviour.

Keywords

Calcium phosphates Drug compounding Ejection force Excipients Friability Hecket plots Lubrication Particle size Powders Tablets Tensile strength 

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Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1993

Authors and Affiliations

  • P. C. Schmidt
    • 1
  • R. Herzog
    • 1
  1. 1.Department of Pharmaceutical TechnologyUniversity of TübingenTübingenFRG

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