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Infection

, Volume 25, Issue 2, pp 90–94 | Cite as

IL-1β and IL-6 in community-acquired pneumonia: Bacteremic pneumococcal pneumonia versusMycoplasma pneumoniae pneumonia

  • D. Lieberman
  • S. Livnat
  • F. Schlaeffer
  • A. Porath
  • S. Horowitz
  • Rachel Levy
Originalia

Summary

Interleukin-1β (IL-1β) and interleukin-6 (IL-6) levels in 20 patients with bacteremicStreptococcus pneumoniae community-acquired pneumonia (CAP) were compared with these cytokine levels in 20 patients withMycoplasma pneumoniae CAP. All 40 patients survived hospitalization and underwent a follow-up examination one month later. Serum IL-1β and IL-6 levels were determined by the enzyme immunoassay (EIA) method using commercial kits. In the acute phase of CAP, IL-6 levels were significantly higher in theS. pneumoniae group (p=0.014), while IL-1β levels were higher in theM. pneumoniae group (p=0.046). In the convalescence phase, the two cytokines were detected in a considerable number of patients in both groups. In this phase, only the level of IL-1β was significantly higher in theM. pneumoniae group than in theS. pneumoniae group (p=0.03). We conclude that the levels of IL-1β and IL-6 are different between patients withS. pneumoniae-CAP andM. pneumoniae-CAP during the acute phase. In the convalescence phase, cytokine levels remain high in some of the CAP patients, but a significant difference between the groups exists only for IL-1β. Further studies are required.

Keywords

Public Health Enzyme Internal Medicine Infectious Disease Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MMV Medizin Verlag GmbH München 1997

Authors and Affiliations

  • D. Lieberman
    • 1
  • S. Livnat
    • 2
  • F. Schlaeffer
    • 2
  • A. Porath
    • 2
  • S. Horowitz
    • 3
  • Rachel Levy
    • 4
  1. 1.Pulmonary Unit, Div. of Internal MedicineBen-Gurion University of the NegevBeer-ShevaIsrael
  2. 2.Div. of Internal MedicineBen-Gurion University of the NegevBeer-ShevaIsrael
  3. 3.National Center for MycoplasmaBen-Gurion University of the NegevBeer-ShevaIsrael
  4. 4.Infectious Diseases Laboratory, Soroka Medical Center of Kupat Holim Klalit and the Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael

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