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Pharmaceutisch Weekblad

, Volume 4, Issue 1, pp 12–15 | Cite as

Hydrochloric acid hydrolysis of bromazepam. Identification and relevance of some additional products

  • M. M. A. de Bruyne
  • A. Sinnema
  • A. M. A. Verweij
Original Articles

Abstract

WithMs andNmr spectroscopic methods the structures of three additional by-products formed in the hydrochloric acid hydrolysis of bromazepam were established. Some attention was paid to the analytical relevance of the by-products and indications are given to perform the hydrolysis in such a way that one specific product can be obtained.

Keywords

Public Health Internal Medicine Hydrochloric Acid Acid Hydrolysis Specific Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • M. M. A. de Bruyne
    • 1
  • A. Sinnema
    • 2
  • A. M. A. Verweij
    • 1
  1. 1.Forensic Science Laboratory of the Ministry of JusticeGd RijswijkThe Netherlands
  2. 2.Laboratory of Organic Chemistry, Department of Chemical TechnologyDelft University of TechnologyBL DelftThe Netherlands

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