The influence of the crystallization on the properties of a hydrophobic drug
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Different phenacetin powders are prepared by recrystallization in water or in aqueous polysorbate 80 solutions. The powders have been characterized by using X-ray diffraction, light microscopy and transmission electron microscopy.
The particle size, surface area and solubilities have been determined. The surface properties of the powders were investigated by measuring the liquid uptake and the amount of polysorbate 80 adsorbed at the crystal surface. The influence of the recrystallization method on the dissolution rate of the powder was studied.
The release of recrystallized phenacetin powders filled into hard gelatin capsules was determined by means of a modified beaker method. An improvement of the hydrophilic properties of the powder enhances the availability of the drug.
KeywordsPublic Health Electron Microscopy Transmission Electron Microscopy Internal Medicine Light Microscopy
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